Biology:ADAM23
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Disintegrin and metalloproteinase domain-containing protein 23 is a non-catalytic protein that in humans is encoded by the ADAM23 gene.[1][2] It is a member of the ADAM family of extracellular matrix metalloproteinases.
Function
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene is highly expressed in the brain and may function as an integrin ligand in the brain.[2]
References
- ↑ "Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain". The Biochemical Journal 334 ( Pt 1) (Pt 1): 93–8. Aug 1998. doi:10.1042/bj3340093. PMID 9693107.
- ↑ 2.0 2.1 "Entrez Gene: ADAM23 ADAM metallopeptidase domain 23". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8745.
Further reading
- "MDC-L, a novel metalloprotease disintegrin cysteine-rich protein family member expressed by human lymphocytes". The Journal of Biological Chemistry 274 (41): 29251–9. Oct 1999. doi:10.1074/jbc.274.41.29251. PMID 10506182.
- "The identification of seven metalloproteinase-disintegrin (ADAM) genes from genomic libraries". Gene 237 (1): 61–70. Sep 1999. doi:10.1016/S0378-1119(99)00302-9. PMID 10524237.
- "ADAM 23/MDC3, a human disintegrin that promotes cell adhesion via interaction with the alphavbeta3 integrin through an RGD-independent mechanism". Molecular Biology of the Cell 11 (4): 1457–69. Apr 2000. doi:10.1091/mbc.11.4.1457. PMID 10749942.
- "Two novel isoforms of Adam23 expressed in the developmental process of mouse and human brains". Gene 325: 171–8. Jan 2004. doi:10.1016/j.gene.2003.10.012. PMID 14697522.
- "Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues". Nature Biotechnology 22 (6): 724–31. Jun 2004. doi:10.1038/nbt969. PMID 15146195.
- "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology 22 (6): 707–16. Jun 2004. doi:10.1038/nbt971. PMID 15146197.
- "ADAM23 methylation and expression analysis in brain tumors". Neuroscience Letters 380 (3): 260–4. Jun 2005. doi:10.1016/j.neulet.2005.01.050. PMID 15862898.
- "Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry". Nature Methods 2 (8): 591–8. Aug 2005. doi:10.1038/nmeth776. PMID 16094384.
- "ADAM23, a possible tumor suppressor gene, is frequently silenced in gastric cancers by homozygous deletion or aberrant promoter hypermethylation". Oncogene 24 (54): 8051–60. Dec 2005. doi:10.1038/sj.onc.1208952. PMID 16103878.
External links
- The MEROPS online database for peptidases and their inhibitors: M12.979
- Human ADAM23 genome location and ADAM23 gene details page in the UCSC Genome Browser.
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