Biology:ADAM22
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Short description: Enzyme found in humans
 Generic protein structure example |
Disintegrin and metalloproteinase domain-containing protein 22, also known as ADAM22, is an enzyme that in humans is encoded by the ADAM22 gene.[1][2][3]
Function
ADAM22 is a member of the ADAM (A Disintegrin And Metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. Alternative splicing results in several transcript variants.[3]
Interactions
ADAM22 has been shown to interact with DLG4.[4]
References
- ↑ "Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain". The Biochemical Journal 334 ( Pt 1) (Pt 1): 93–8. August 1998. doi:10.1042/bj3340093. PMID 9693107.
- ↑ "The identification of seven metalloproteinase-disintegrin (ADAM) genes from genomic libraries". Gene 237 (1): 61–70. September 1999. doi:10.1016/S0378-1119(99)00302-9. PMID 10524237.
- ↑ 3.0 3.1 "Entrez Gene: ADAM22 ADAM metallopeptidase domain 22". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=53616.
- ↑ "Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission". Science 313 (5794): 1792–5. September 2006. doi:10.1126/science.1129947. PMID 16990550. Bibcode: 2006Sci...313.1792F.
Further reading
- "The specific expression of three novel splice variant forms of human metalloprotease-like disintegrin-like cysteine-rich protein 2 gene inBrain tissues and gliomas". Japanese Journal of Cancer Research 91 (10): 1001–6. October 2000. doi:10.1111/j.1349-7006.2000.tb00877.x. PMID 11050470.
- "The interaction between ADAM 22 and 14-3-3zeta: regulation of cell adhesion and spreading". Biochemical and Biophysical Research Communications 301 (4): 991–9. February 2003. doi:10.1016/S0006-291X(03)00056-1. PMID 12589811.
- "An unappreciated role for RNA surveillance". Genome Biology 5 (2): R8. 2005. doi:10.1186/gb-2004-5-2-r8. PMID 14759258.
- "Ataxia and peripheral nerve hypomyelination in ADAM22-deficient mice". BMC Neuroscience 6: 33. 2006. doi:10.1186/1471-2202-6-33. PMID 15876356.
- "ADAM22 plays an important role in cell adhesion and spreading with the assistance of 14-3-3". Biochemical and Biophysical Research Communications 331 (4): 938–46. June 2005. doi:10.1016/j.bbrc.2005.03.229. PMID 15882968.
- "ADAM22, expressed in normal brain but not in high-grade gliomas, inhibits cellular proliferation via the disintegrin domain". Neurosurgery 58 (1): 179–86; discussion 179–86. January 2006. doi:10.1227/01.NEU.0000192363.84287.8B. PMID 16385342.
- "Efficient ADAM22 surface expression is mediated by phosphorylation-dependent interaction with 14-3-3 protein family members". Journal of Cell Science 119 (Pt 16): 3296–305. August 2006. doi:10.1242/jcs.03065. PMID 16868027.
- "Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission". Science 313 (5794): 1792–5. September 2006. doi:10.1126/science.1129947. PMID 16990550. Bibcode: 2006Sci...313.1792F.
- "Absence of mutations in the LGI1 receptor ADAM22 gene in autosomal dominant lateral temporal epilepsy". Epilepsy Research 76 (1): 41–8. August 2007. doi:10.1016/j.eplepsyres.2007.06.014. PMID 17681454. http://www.hal.inserm.fr/inserm-00306474/file/Chabrol_et_al_Epi_Research-2007.pdf.
- "Differential coding potential of ADAM22 mRNAs". Gene 403 (1–2): 80–8. November 2007. doi:10.1016/j.gene.2007.07.033. PMID 17884303.
External links
- The MEROPS online database for peptidases and their inhibitors: M12.978
- Human ADAM22 genome location and ADAM22 gene details page in the UCSC Genome Browser.
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