Biology:ADAM8
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
A Disintegrin and metalloproteinase domain-containing protein 8 is an enzyme that in humans is encoded by the ADAM8 gene.[1][2]
Function
This gene encodes a member of the ADAM (a disintegrin and metalloproteinase domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell–cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration.[2]
See also
References
- ↑ "CD156 (human ADAM8): expression, primary amino acid sequence, and gene location". Genomics 41 (1): 56–62. April 1997. doi:10.1006/geno.1997.4607. PMID 9126482.
- ↑ 2.0 2.1 "Entrez Gene: ADAM8 ADAM metallopeptidase domain 8". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=101.
Further reading
- "ADAM family proteins in the immune system". Immunology Today 20 (6): 278–84. June 1999. doi:10.1016/S0167-5699(99)01464-4. PMID 10354553.
- "Tumor necrosis factor alpha induces a metalloprotease-disintegrin, ADAM8 (CD 156): implications for neuron-glia interactions during neurodegeneration". The Journal of Neuroscience 20 (21): 7964–71. November 2000. doi:10.1523/JNEUROSCI.20-21-07964.2000. PMID 11050116.
- "The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPs". FEBS Letters 524 (1–3): 154–8. July 2002. doi:10.1016/S0014-5793(02)03047-8. PMID 12135759.
- "ADAM8 as a novel serological and histochemical marker for lung cancer". Clinical Cancer Research 10 (24): 8363–70. December 2004. doi:10.1158/1078-0432.CCR-04-1436. PMID 15623614.
- "Increased expression of ADAM33 and ADAM8 with disease progression in asthma". The Journal of Allergy and Clinical Immunology 119 (4): 863–71. April 2007. doi:10.1016/j.jaci.2006.12.665. PMID 17339047.
- "Expression and regulation of the metalloproteinase ADAM-8 during human neutrophil pathophysiological activation and its catalytic activity on L-selectin shedding". Journal of Immunology 178 (12): 8053–63. June 2007. doi:10.4049/jimmunol.178.12.8053. PMID 17548643.
- "ADAM8 expression is associated with increased invasiveness and reduced patient survival in pancreatic cancer". Journal of Cellular and Molecular Medicine 11 (5): 1162–74. 2008. doi:10.1111/j.1582-4934.2007.00082.x. PMID 17979891.
External links
- The MEROPS online database for peptidases and their inhibitors: M12.208
- ADAM8 human gene location in the UCSC Genome Browser.
- ADAM8 human gene details in the UCSC Genome Browser.
- PDBe-KB provides an overview of all the structure information available in the PDB for Human Disintegrin and metalloproteinase domain-containing protein 8 (ADAM8)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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