Biology:Mevaldate reductase
From HandWiki
| mevaldate reductase (NAD+) | |||||||||
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| Identifiers | |||||||||
| EC number | 1.1.1.32 | ||||||||
| CAS number | 9028-33-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a mevaldate reductase (EC 1.1.1.32) is an enzyme that catalyzes the chemical reaction
- (R)-mevalonate + NAD+ [math]\displaystyle{ \rightleftharpoons }[/math] mevaldate + NADH + H+
Thus, the two substrates of this enzyme are (R)-mevalonate and NAD+, whereas its 3 products are mevaldate, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-mevalonate:NAD+ oxidoreductase. This enzyme is also called mevalonic dehydrogenase.
References
- "Reduction of mevaldic acid to mevalonic acid by a partial purified enzyme from liver". J. Biol. Chem. 236: 2421–2424. 1961.
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