Biology:Mevaldate reductase (NADPH)

From HandWiki
mevaldate reductase (NADPH)
Identifiers
EC number1.1.1.33
CAS number9028-34-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a mevaldate reductase (NADPH) (EC 1.1.1.33) is an enzyme that catalyzes the chemical reaction

(R)-mevalonate + NADP+ [math]\displaystyle{ \rightleftharpoons }[/math] mevaldate + NADPH + H+

Thus, the two substrates of this enzyme are (R)-mevalonate and NADP+, whereas its 3 products are mevaldate, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-mevalonate:NADP+ oxidoreductase. Other names in common use include mevaldate (reduced nicotinamide adenine dinucleotide phosphate), reductase, and mevaldate reductase (NADPH).

References

  • "Mevaldate reductase (NADPH)". Enzyme Handbook 9. 9. Berlin, Heidelberg: Springer. 1995. pp. 189–191. doi:10.1007/978-3-642-85200-8_33. ISBN 978-3-642-85200-8. 
  • CIBA Symposium on the Biosynthesis of Terpenes and Sterols. London. 1959. pp. 62–74. 
  • Enzymatic Basis of Detoxication. 1. New York: Academic Press. 1980. pp. 249–260.