Biology:Mevaldate reductase (NADPH)
From HandWiki
mevaldate reductase (NADPH) | |||||||||
---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||
EC number | 1.1.1.33 | ||||||||
CAS number | 9028-34-6 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
|
In enzymology, a mevaldate reductase (NADPH) (EC 1.1.1.33) is an enzyme that catalyzes the chemical reaction
- (R)-mevalonate + NADP+ [math]\displaystyle{ \rightleftharpoons }[/math] mevaldate + NADPH + H+
Thus, the two substrates of this enzyme are (R)-mevalonate and NADP+, whereas its 3 products are mevaldate, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-mevalonate:NADP+ oxidoreductase. Other names in common use include mevaldate (reduced nicotinamide adenine dinucleotide phosphate), reductase, and mevaldate reductase (NADPH).
References
- "Mevaldate reductase (NADPH)". Enzyme Handbook 9. 9. Berlin, Heidelberg: Springer. 1995. pp. 189–191. doi:10.1007/978-3-642-85200-8_33. ISBN 978-3-642-85200-8.
- CIBA Symposium on the Biosynthesis of Terpenes and Sterols. London. 1959. pp. 62–74.
- Enzymatic Basis of Detoxication. 1. New York: Academic Press. 1980. pp. 249–260.
![]() | Original source: https://en.wikipedia.org/wiki/Mevaldate reductase (NADPH).
Read more |