Biology:Microtubule-severing ATPase
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Short description: Class of enzymes
| microtubule-severing ATPase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.6.4.3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a microtubule-severing ATPase (EC 3.6.4.3) is an enzyme that catalyzes the chemical reaction
- ATP + H2O [math]\displaystyle{ \rightleftharpoons }[/math] ADP + phosphate
Thus, the two substrates of this enzyme are ATP and H2O, whereas its two products are ADP and phosphate.
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to facilitate cellular and subcellular movement. The systematic name of this enzyme class is ATP phosphohydrolase (tubulin-dimerizing).
See also
References
- "Identification of katanin, an ATPase that severs and disassembles stable microtubules". Cell 75 (3): 419–29. 1993. doi:10.1016/0092-8674(93)90377-3. PMID 8221885.
- "Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit". Cell 93 (2): 277–87. 1998. doi:10.1016/S0092-8674(00)81578-0. PMID 9568719.
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