Biology:Pheophorbide a oxygenase
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Short description: Class of enzymes
| Pheophorbide a oxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.14.15.17 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Pheophorbide a oxygenase (EC 1.14.15.17, pheide a monooxygenase, pheide a oxygenase, PAO) is an enzyme with systematic name pheophorbide-a,NADPH:oxygen oxidoreductase (biladiene-forming).[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction
- Pheophorbide a + NADPH + H+ + O2 [math]\displaystyle{ \rightleftharpoons }[/math] red chlorophyll catabolite + NADP+
Pheophorbide a oxygenase participates in chlorophyll degradation. Loss-of-function mutations in the gene can lead to a stay-green phenotype in plants.[7]
References
- ↑ "The key step in chlorophyll breakdown in higher plants. Cleavage of pheophorbide a macrocycle by a monooxygenase". The Journal of Biological Chemistry 273 (25): 15335–9. June 1998. doi:10.1074/jbc.273.25.15335. PMID 9624113.
- ↑ "Chlorophyll breakdown: pheophorbide a oxygenase is a Rieske-type iron-sulfur protein, encoded by the accelerated cell death 1 gene". Proceedings of the National Academy of Sciences of the United States of America 100 (25): 15259–64. December 2003. doi:10.1073/pnas.2036571100. PMID 14657372.
- ↑ "The role of pheophorbide a oxygenase expression and activity in the canola green seed problem". Plant Physiology 142 (1): 88–97. September 2006. doi:10.1104/pp.106.084483. PMID 16844830.
- ↑ "Chlorophyll Breakdown in Senescent Chloroplasts (Cleavage of Pheophorbide a in Two Enzymic Steps)". Plant Physiology 115 (2): 669–676. October 1997. doi:10.1104/pp.115.2.669. PMID 12223835.
- ↑ "Chlorophyll degradation during senescence". Annual Review of Plant Biology 57: 55–77. 2006. doi:10.1146/annurev.arplant.57.032905.105212. PMID 16669755.
- ↑ "In vivo participation of red chlorophyll catabolite reductase in chlorophyll breakdown". The Plant Cell 19 (1): 369–87. January 2007. doi:10.1105/tpc.106.044404. PMID 17237353.
- ↑ Bachmann, Andre; Fernandez-Lopez, Jose; Ginsburg, Samuel; Thomas, Howard; Bouwcamp, John C; Solomos, Theophanes; Matile, Phillipe (1994). "Stay-green genotypes of Phaseolus vulgaris L.: chloroplast proteins and chlorophyll catabolites during foliar senescence". New Phytologist 126 (4): 593–600. doi:10.1111/j.1469-8137.1994.tb02953.x.
External links
- Pheophorbide+a+oxygenase at the US National Library of Medicine Medical Subject Headings (MeSH)
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