Biology:Phosphogluconate 2-dehydrogenase
| phosphogluconate 2-dehydrogenase | |||||||||
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| Identifiers | |||||||||
| EC number | 1.1.1.43 | ||||||||
| CAS number | 9001-82-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a phosphogluconate 2-dehydrogenase (EC 1.1.1.43) is an enzyme that catalyzes the chemical reaction
- 6-phospho-D-gluconate + NAD(P)+ [math]\displaystyle{ \rightleftharpoons }[/math] 6-phospho-2-dehydro-D-gluconate + NAD(P)H + H+
The 3 substrates of this enzyme are 6-phospho-D-gluconic acid, NAD+, and NADP+, whereas its 4 products are 6-phospho-2-dehydro-D-gluconic acid, NADH, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 6-phospho-D-gluconate:NAD(P)+ 2-oxidoreductase. Other names in common use include 6-phosphogluconic dehydrogenase, phosphogluconate dehydrogenase, gluconate 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase (NAD+), and 2-keto-6-phosphogluconate reductase. This enzyme participates in pentose phosphate pathway and glutathione metabolism.
References
- "Carbohydrate oxidation by Pseudomonas fluorescens VI. Conversion of 2-keto-6-phosphogluconate to pyruvate". J. Biol. Chem. 236: 2571–2577. 1961. PMID 13894458.
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