Biology:Ribitol 2-dehydrogenase
From HandWiki
| ribitol 2-dehydrogenase | |||||||||
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| Identifiers | |||||||||
| EC number | 1.1.1.56 | ||||||||
| CAS number | 9014-23-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a ribitol 2-dehydrogenase (EC 1.1.1.56) is an enzyme that catalyzes the chemical reaction
- ribitol + NAD+ [math]\displaystyle{ \rightleftharpoons }[/math] D-ribulose + NADH + H+
Thus, the two substrates of this enzyme are ribitol and NAD+, whereas its 3 products are D-ribulose, NADH, and H+.
This enzyme participates in pentose and glucuronate interconversions.
Nomenclature
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is ribitol:NAD+ 2-oxidoreductase. Other names in common use include adonitol dehydrogenase, ribitol dehydrogenase A (wild type), ribitol dehydrogenase B (mutant enzyme with different properties), and ribitol dehydrogenase D (mutant enzyme with different properties).
References
- "The L-xylulose-xylitol enzyme and other polyol dehydrogenases of guinea pig liver mitochondria". The Journal of Biological Chemistry 225 (1): 87–102. Mar 1957. PMID 13416220.
- "Ribitol dehydrogenase. II. Studies on the reaction mechanism". The Journal of Biological Chemistry 234: 2523–31. Oct 1959. PMID 14427582.
- "Ribitol and D-arabitol utilization by Aerobacter aerogenes". The Journal of Biological Chemistry 236: 2190–5. Aug 1961. PMID 13786517.
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