Biology:Ribostamycin:4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoyl-(BtrI acyl-carrier protein) 4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoate transferase
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| Ribostamycin:4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoyl-(BtrI acyl-carrier protein) 4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoate transferase | |||||||||
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| Identifiers | |||||||||
| EC number | 2.3.2.19 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Ribostamycin:4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoyl-(BtrI acyl-carrier protein) 4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoate transferase (EC 2.3.2.19, btrH (gene)) is an enzyme with systematic name ribostamycin:4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoyl-(BtrI acyl-carrier protein) 4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoate transferase.[1] This enzyme catalyses the following chemical reaction
- 4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoyl-[BtrI acyl-carrier protein] + ribostamycin [math]\displaystyle{ \rightleftharpoons }[/math] gamma-L-glutamyl-butirosin B + BtrI acyl-carrier protein
The enzyme attaches the side chain of the aminoglycoside antibiotics of the butirosin family.
References
- ↑ "Biosynthesis of butirosin: transfer and deprotection of the unique amino acid side chain". Chemistry & Biology 14 (4): 379–86. April 2007. doi:10.1016/j.chembiol.2007.02.005. PMID 17462573.
External links
- Ribostamycin:4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoyl-(BtrI+acyl-carrier+protein)+4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoate+transferase at the US National Library of Medicine Medical Subject Headings (MeSH)
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