Biology:S-(hydroxymethyl)mycothiol dehydrogenase
From HandWiki
| S-(hydroxymethyl)mycothiol dehydrogenase | |||||||||
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| Identifiers | |||||||||
| EC number | 1.1.1.306 | ||||||||
| CAS number | 192140-85-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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S-(hydroxymethyl)mycothiol dehydrogenase (EC 1.1.1.306, NAD/factor-dependent formaldehyde dehydrogenase, mycothiol-dependent formaldehyde dehydrogenase) is an enzyme with systematic name S-(hydroxymethyl)mycothiol:NAD+ oxidoreductase.[1][2][3][4] This enzyme catalyses the following chemical reaction
- S-(hydroxymethyl)mycothiol + NAD+ [math]\displaystyle{ \rightleftharpoons }[/math] S-formylmycothiol + NADH + H+
S-hydroxymethylmycothiol forms spontaneously from formaldehyde and mycothiol.
References
- ↑ "Mycothiol, 1-O-(2'-[N-acetyl-L-cysteinyl]amido-2'-deoxy-alpha-D-glucopyranosyl)-D- myo-inositol, is the factor of NAD/factor-dependent formaldehyde dehydrogenase". FEBS Letters 409 (2): 221–2. June 1997. doi:10.1016/S0014-5793(97)00510-3. PMID 9202149.
- ↑ "Mycothiol-dependent formaldehyde dehydrogenase, a prokaryotic medium-chain dehydrogenase/reductase, phylogenetically links different eukaroytic alcohol dehydrogenases--primary structure, conformational modelling and functional correlations". European Journal of Biochemistry 248 (2): 282–9. September 1997. doi:10.1111/j.1432-1033.1997.00282.x. PMID 9346279.
- ↑ "The metabolism of nitrosothiols in the Mycobacteria: identification and characterization of S-nitrosomycothiol reductase". The Biochemical Journal 374 (Pt 3): 657–66. September 2003. doi:10.1042/BJ20030642. PMID 12809551.
- ↑ "Mycothiol-dependent proteins in actinomycetes". FEMS Microbiology Reviews 31 (3): 278–92. April 2007. doi:10.1111/j.1574-6976.2006.00062.x. PMID 17286835.
External links
- S-(hydroxymethyl)mycothiol+dehydrogenase at the US National Library of Medicine Medical Subject Headings (MeSH)
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