Biology:SLC1A1

Generic protein structure example

SLC1A1, also known as excitatory amino-acid transporter 3 (EAAT3), is a protein that in humans is encoded by the SLC1A1 gene.

Function

Excitatory amino-acid transporter 3 is a member of the high-affinity glutamate transporters which plays an essential role in transporting glutamate across plasma membranes in neurons. In the brain, excitatory amino acid transporters are crucial in terminating the postsynaptic action of the neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. EAAT3 also transports aspartate, and mutations in this gene are thought to cause dicarboxylic aminoaciduria, also known as glutamate-aspartate transport defect. EAAT3 is also the major route of neuronal cysteine uptake. Cysteine is a component of the major antioxidant glutathione, and mice lacking EAAT3 exhibit reduced levels of glutathione in neurons, increased oxidative stress, and age-dependent loss of neurons, especially neurons of the substantia nigra.

Interactions

SLC1A1 has been shown to interact with ARL6IP5.

See also

• Excitatory amino acid transporter
• Glutamate transporter
• Solute carrier family

Further reading

• "The neuronal excitatory amino acid transporter EAAC1/EAAT3: does it represent a major actor at the brain excitatory synapse?". J. Neurochem. 98 (4): 1007–18. 2006. doi:10.1111/j.1471-4159.2006.03978.x. PMID 16800850. 
• "Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex". J. Neurosci. 14 (9): 5559–69. 1994. PMID 7521911. 
• "Neuron-specific human glutamate transporter: molecular cloning, characterization and expression in human brain". Brain Res. 662 (1-2): 245–50. 1994. doi:10.1016/0006-8993(94)90819-2. PMID 7859077. 
• "The neuronal and epithelial human high affinity glutamate transporter. Insights into structure and mechanism of transport". J. Biol. Chem. 269 (32): 20599–606. 1994. PMID 7914198. 
• "Interaction of L-cysteine with a human excitatory amino acid transporter". J. Physiol. 493 (Pt 2): 419–23. 1996. doi:10.1113/jphysiol.1996.sp021393. PMID 8782106. 
• "Distribution of glutamate transporter subtypes during human brain development". J. Neurochem. 69 (6): 2571–80. 1997. doi:10.1046/j.1471-4159.1997.69062571.x. PMID 9375691. 
• "Differential synaptic localization of the glutamate transporter EAAC1 and glutamate receptor subunit GluR2 in the rat hippocampus". J. Comp. Neurol. 418 (3): 255–69. 2000. doi:10.1002/(SICI)1096-9861(20000313)418:3<255::AID-CNE2>3.0.CO;2-6. PMID 10701825. 
• "Modulation of the neuronal glutamate transporter EAAC1 by the interacting protein GTRAP3-18". Nature 410 (6824): 84–8. 2001. doi:10.1038/35065084. PMID 11242046. 
• "Genomic organization of the SLC1A1/EAAC1 gene and mutation screening in early-onset obsessive-compulsive disorder". Mol. Psychiatry 6 (2): 160–7. 2001. doi:10.1038/sj.mp.4000806. PMID 11317217. 
• "Dynamic equilibrium between coupled and uncoupled modes of a neuronal glutamate transporter". J. Biol. Chem. 277 (16): 13501–7. 2002. doi:10.1074/jbc.M110861200. PMID 11823462. 
• "Phorbol myristate acetate-dependent interaction of protein kinase Calpha and the neuronal glutamate transporter EAAC1". J. Neurosci. 23 (13): 5589–93. 2003. PMID 12843260. 
• "Distribution of glutamate transporters in the human placenta". Placenta 25 (6): 489–95. 2004. doi:10.1016/j.placenta.2003.10.018. PMID 15135231. 
• "Small-scale molecular motions accomplish glutamate uptake in human glutamate transporters". J. Neurosci. 25 (7): 1730–6. 2005. doi:10.1523/JNEUROSCI.4138-04.2005. PMID 15716409. 
• "Increased expression and function of glutamate transporters in multiple sclerosis". Neurobiol. Dis. 21 (1): 154–64. 2006. doi:10.1016/j.nbd.2005.06.017. PMID 16061389. 
• "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. 
• "GABA and glutamate transporters are expressed in human platelets". Brain Res. Mol. Brain Res. 141 (2): 161–5. 2005. doi:10.1016/j.molbrainres.2005.08.013. PMID 16198020. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.