Biology:Taurochenodeoxycholate 6α-hydroxylase
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Short description: Class of enzymes
| Taurochenodeoxycholate 6alpha-hydroxylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.14.13.97 | ||||||||
| CAS number | 105669-85-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Taurochenodeoxycholate 6alpha-hydroxylase (EC 1.14.13.97, CYP3A4, CYP4A21, taurochenodeoxycholate 6alpha-monooxygenase) is an enzyme with systematic name taurochenodeoxycholate,NADPH:oxygen oxidoreductase (6alpha-hydroxylating).[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction
- (1) taurochenodeoxycholate + NADPH + H+ + O2 [math]\displaystyle{ \rightleftharpoons }[/math] taurohyocholate + NADP+ + H2O
- (2) lithocholate + NADPH + H+ + O2 [math]\displaystyle{ \rightleftharpoons }[/math] hyodeoxycholate + NADP+ + H2O
Taurochenodeoxycholate 6α-hydroxylase is a heme-thiolate protein (P-450).
See also
References
- ↑ "6alpha-hydroxylation of taurochenodeoxycholic acid and lithocholic acid by CYP3A4 in human liver microsomes". Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1438 (1): 47–54. April 1999. doi:10.1016/s1388-1981(99)00031-1. PMID 10216279.
- ↑ "Characterisation of taurochenodeoxycholic acid 6 alpha-hydroxylase from pig liver microsomes". European Journal of Biochemistry 231 (3): 855–61. August 1995. doi:10.1111/j.1432-1033.1995.0855d.x. PMID 7649186.
- ↑ "Identification of the bile acid-binding site of the ileal lipid-binding protein by photoaffinity labeling, matrix-assisted laser desorption ionization-mass spectrometry, and NMR structure". The Journal of Biological Chemistry 276 (10): 7291–301. March 2001. doi:10.1074/jbc.M006877200. PMID 11069906.
- ↑ "Cloning and expression of a pig liver taurochenodeoxycholic acid 6alpha-hydroxylase (CYP4A21): a novel member of the CYP4A subfamily". The Journal of Biological Chemistry 276 (13): 9606–12. March 2001. doi:10.1074/jbc.M006584200. PMID 11113117.
- ↑ "Gene structure of pig sterol 12alpha-hydroxylase (CYP8B1) and expression in fetal liver: comparison with expression of taurochenodeoxycholic acid 6alpha-hydroxylase (CYP4A21)". Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1634 (3): 86–96. November 2003. doi:10.1016/j.bbalip.2003.09.002. PMID 14643796.
- ↑ "The enzymes, regulation, and genetics of bile acid synthesis". Annual Review of Biochemistry 72: 137–74. 2003. doi:10.1146/annurev.biochem.72.121801.161712. PMID 12543708.
External links
- Taurochenodeoxycholate+6alpha-hydroxylase at the US National Library of Medicine Medical Subject Headings (MeSH)
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