Biology:Vellosimine dehydrogenase
From HandWiki
| vellosimine dehydrogenase | |||||||||
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| Identifiers | |||||||||
| EC number | 1.1.1.273 | ||||||||
| CAS number | 86777-26-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a vellosimine dehydrogenase (EC 1.1.1.273) is an enzyme that catalyzes the chemical reaction
- 10-deoxysarpagine + NADP+ [math]\displaystyle{ \rightleftharpoons }[/math] vellosimine + NADPH + H+
Thus, the two substrates of this enzyme are 10-deoxysarpagine and NADP+, whereas its 3 products are vellosimine, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 10-deoxysarpagine:NADP+ oxidoreductase. This enzyme participates in indole and ipecac alkaloid biosynthesis.
References
- "Characteristics of vellosimine reductase, a specific enzyme involved in the biosynthesis of the Rauwolfia alkaloid sarpagine". Tetrahedron 40 (10): 1691–1699. 1984. doi:10.1016/S0040-4020(01)91118-4.
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