Biology:Vitamin D3 24-hydroxylase
From HandWiki
Short description: Class of enzymes
| Vitamin D3 24-hydroxylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.14.15.16 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Vitamin D3 24-hydroxylase (EC 1.14.15.16, CYP24A1) is an enzyme with systematic name calcitriol,NADPH:oxygen oxidoreductase (24-hydroxylating).[1][2][3][4][5][6][7] This enzyme catalyses the following chemical reaction
- (1) calcitriol + NADPH + H+ + O2 [math]\displaystyle{ \rightleftharpoons }[/math] calcitetrol + NADP+ + H2O
- (2) calcidiol + NADPH + H+ + O2 [math]\displaystyle{ \rightleftharpoons }[/math] secalciferol + NADP+ + H2O
Vitamin D3 24-hydroxylase is a heme-thiolate enzyme (P-450).
References
- ↑ "Evidence for the activation of 1alpha-hydroxyvitamin D2 by 25-hydroxyvitamin D-24-hydroxylase: delineation of pathways involving 1alpha,24-dihydroxyvitamin D2 and 1alpha,25-dihydroxyvitamin D2". Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1761 (2): 221–34. February 2006. doi:10.1016/j.bbalip.2006.01.004. PMID 16516540.
- ↑ "Structure-function analysis of vitamin D 24-hydroxylase (CYP24A1) by site-directed mutagenesis: amino acid residues responsible for species-based difference of CYP24A1 between humans and rats". Molecular Pharmacology 70 (1): 120–8. July 2006. doi:10.1124/mol.106.023275. PMID 16617161.
- ↑ "Metabolism of vitamin D3 by cytochromes P450". Frontiers in Bioscience 10: 119–34. January 2005. doi:10.2741/1514. PMID 15574355.
- ↑ "Single A326G mutation converts human CYP24A1 from 25-OH-D3-24-hydroxylase into -23-hydroxylase, generating 1alpha,25-(OH)2D3-26,23-lactone". Proceedings of the National Academy of Sciences of the United States of America 104 (31): 12673–8. July 2007. doi:10.1073/pnas.0702093104. PMID 17646648. Bibcode: 2007PNAS..10412673P.
- ↑ "Metabolism of A-ring diastereomers of 1alpha,25-dihydroxyvitamin D3 by CYP24A1". Biochemical and Biophysical Research Communications 321 (4): 774–82. September 2004. doi:10.1016/j.bbrc.2004.07.040. PMID 15358094.
- ↑ "Novel metabolism of 1 alpha,25-dihydroxyvitamin D3 with C24-C25 bond cleavage catalyzed by human CYP24A1". Biochemistry 43 (15): 4530–7. April 2004. doi:10.1021/bi030207f. PMID 15078099.
- ↑ "Enzymes involved in the activation and inactivation of vitamin D". Trends in Biochemical Sciences 29 (12): 664–73. December 2004. doi:10.1016/j.tibs.2004.10.005. PMID 15544953.
External links
- Vitamin+D3+24-hydroxylase at the US National Library of Medicine Medical Subject Headings (MeSH)
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