Chemistry:Gadolinium(III) hydroxide
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| Names | |
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| Systematic IUPAC name
Gandolinium trihydroxide | |
Other names
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3D model (JSmol)
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PubChem CID
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| Properties | |
| Gd(OH)3 | |
| Molar mass | 208.3 g/mol |
| Appearance | White solid |
| Melting point | 307 °C (585 °F; 580 K)[1] (decomposes) |
| Insoluble | |
| Structure | |
| Hexagonal[2] | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
Gadolinium(III) hydroxide is a chemical compound with the formula Gd(OH)3. Its nanoparticles has a potential use for layering various drugs, such as diclofenac, ibuprofen, and naproxen.
Production and properties
Gadolinium(III) hydroxide can be produced in various ways such as the reaction of gadolinium(III) nitrate and sodium hydroxide:[1]
- Gd(NO3)3 + NaOH → Gd(OH)3 + NaNO3
If this compound is heated to 307 °C, it decomposes to gadolinium(III) oxide-hydroxide(GdOOH), which in turn decomposes to gadolinium(III) oxide if continually heated.[1]
Uses
Gadolinium(III) hydroxide has no commercial uses. However, gadolinium(III) hydroxide nanoparticles have gained interest as a coating agent for various anti-inflammatory drugs such as diclofenac, ibuprofen, and naproxen[3] due to their property to be non-cytotoxic.[4] The nanoparticles are produced by adding base anion exchange resin to gadolinium(III) nitrate.[2]
References
- ↑ 1.0 1.1 1.2 Logvinenko, V.; Bakovets, V.; Trushnikova, L. (2014). "Dehydroxylation kinetics of gadolinium hydroxide." (in en). Journal of Thermal Analysis and Calorimetry 115 (1): 517–521. doi:10.1007/s10973-013-3274-1.
- ↑ 2.0 2.1 Y. Kobayashi; H. Morimoto; T. Nakagawa; Y. Kubota; K.Gonda; N. Ohuchi (2016). "Fabrication of gadolinium hydroxide nanoparticles using ion-exchange resin and their MRI property" (in en). Journal of Asian Ceramic Societies 4 (1): 138–142. doi:10.1016/j.jascer.2016.01.005.
- ↑ Yadong Xu; Alvaro Goyanes; Yuwei Wang; Andrew J. Weston; Po-Wah So; Carlos F. G. C. Geraldes; Andrew M. Fogg; Abdul W. Basit et al. (2018). "Layered gadolinium hydroxides for simultaneous drug delivery and imaging" (in en). Dalton Transactions 47 (9): 3166–3177. doi:10.1039/C7DT03729E. PMID 29355263.
- ↑ Hemmer, Eva; Kohl, Yvonne; Colquhoun, Victoria; Thielecke, Hagen; Soga, Kohei; Mathur, Sanjay (2010). "Probing Cytotoxicity of Gadolinium Hydroxide Nanostructures" (in en). The Journal of Physical Chemistry B 114 (12): 4358–4365. doi:10.1021/jp911607h. PMID 20218658.
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