Iohexol, sold under the trade name Omnipaque among others, is a contrast agent used during X-rays. This includes when visualizing arteries, veins, ventricles of the brain, the urinary system, and joints, as well as during computer tomography (CT scan). It is given by mouth, injection into a vein, or into a body cavity.
Side effects include vomiting, skin flushing, headache, itchiness, kidney problems, and low blood pressure. Less commonly allergic reactions or seizures may occur. Allergies to povidone-iodine or shellfish do not affect the risk of side effects more than other allergies. Use in the later part of pregnancy may cause hypothyroidism in the baby. Iohexol is an iodinated non-ionic radiocontrast agent. It is in the low osmolar family.
Iohexol was approved for medical use in 1985. It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system. The wholesale cost in the developing world is about US$10.99 per 50 ml vial. In the United States a dose costs US$50–100.
The osmolality of iohexol ranges from 322 mOsm/kg—approximately 1.1 times that of blood plasma—to 844 mOsm/kg, almost three times that of blood. Despite this difference, iohexol is still considered a low-osmolality contrast agent; the osmolality of older agents, such as diatrizoate, may be more than twice as high.
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It is available in various concentrations, from 140 to 350 milligrams of iodine per milliliter.
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- "Iohexol". http://mshpriceguide.org/en/single-drug-information/?DMFId=438&searchYear=2014. Retrieved 8 December 2016.
- GE Healthcare (May 2006). "Omnipaque (Iohexol) injection. Product label". DailyMed. U.S. National Library of Medicine. http://dailymed.nlm.nih.gov/dailymed/fdaDrugXsl.cfm?id=3465&type=display. Retrieved 2007-03-28.
- Amersham Health (April 2006). "Hypaque (Diatrizoate Meglumine and Diatrizoate Sodium) injection, solution. Product label". DailyMed. U.S. National Library of Medicine. Archived from the original on 2011-05-23. https://web.archive.org/web/20110523223457/http://dailymed.nlm.nih.gov/dailymed/fdaDrugXsl.cfm?id=997&type=display. Retrieved 2007-03-29.
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Original source: https://en.wikipedia.org/wiki/ Iohexol. Read more