Chemistry:Libiguin A
 | |
| Clinical data | |
|---|---|
| Drug class | Pro-sexual agent |
| ATC code |
|
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| Chemical and physical data | |
| Formula | C37H46O13 |
| Molar mass | 698.762 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
Libiguin A is a naturally occurring limonoid found in Neobeguea mahafalensis, a flowering plant found in Madagascar with a long history of traditional medical use.[1][2][3][4][5] It is a derivative of phragmalin.[1] The compound has been reported to produce highly potent, strong, and long-lasting pro-sexual effects in rodents.[1][5] The semisynthesis of libiguin A from phragmalin has been described.[2] An analogue also found in Neobeguea mahafalensis, libiguin B, has similar pro-sexual effects but is far less potent in comparison.[1][2][5] Another analogue, a synthetic compound known as volufralin (LIB-01; DIC-2024), is under development for the treatment of erectile dysfunction and premature ejaculation.[6][7] Libiguin A was first described in the scientific literature by 2014.[1][2]
See also
References
- ↑ 1.0 1.1 1.2 1.3 1.4 "Libiguins A and B: novel phragmalin limonoids isolated from Neobeguea mahafalensis causing profound enhancement of sexual activity". Planta Medica 80 (4): 306–314. March 2014. doi:10.1055/s-0033-1360390. PMID 24549927.
- ↑ 2.0 2.1 2.2 2.3 "Semisynthesis of libiguin A and its analogues by trans-lactonization of phragmalin". The Journal of Organic Chemistry 79 (9): 4148–4153. May 2014. doi:10.1021/jo500318w. PMID 24716657.
- ↑ "New Polyfunctional Phragmalin Limonoids from Neobeguea mahafalensis". Planta Medica 82 (11–12): 1087–1095. July 2016. doi:10.1055/s-0042-108741. PMID 27340794.
- ↑ "Recent progress in the chemistry and biology of limonoids". RSC Advances 7 (56): 35191–35220. 2017. doi:10.1039/c7ra04715k. ISSN 2046-2069. "3.1.14. Neobeguea. As described in Fig. 15, 11 new limonoids, namely, dodoguin 313, dormir A–G 314–320, 108 libiguins A 321, libiguins B (a) 322 and libiguins B (b) 323, 109 were isolated from the root barks of Neobeguea mahafalensis, a medicinal plant in Madagascar. Interestingly, compounds 318, and 321–323 contained a C-16/30 d-lactone ring, which was the rst time reported in this species. [...] compound 322 exhibited a potent sexual enhancing activity.".
- ↑ 5.0 5.1 5.2 "Triterpenoids". Natural Product Reports 35 (12): 1294–1329. December 2018. doi:10.1039/c8np00029h. PMID 29993074. "Neobeguea mahafalensis is the source of the phragmalin derivatives libiguin A 560 and libiguin B 561 (in equilibrium with its keto tautomer).202 These compounds are reported to have aphrodisiac properties.".
- ↑ "LIB 01". 26 December 2025. https://adisinsight.springer.com/drugs/800047257.
- ↑ "A new approach could radically change erectile dysfunction treatment". 12 January 2026. https://www.drugdiscoverynews.com/a-new-approach-could-radically-change-erectile-dysfunction-treatment-16910.
 |  |
