Chemistry:Methazolamide
From HandWiki
Methazolamide (trade name Neptazane) is a potent carbonic anhydrase inhibitor. It is indicated in the treatment of increased intraocular pressure (IOP) in chronic open-angle glaucoma and secondary glaucoma. Also it is used preoperatively in acute angle-closure (narrow-angle) glaucoma where lowering the IOP is desired before surgery.
This drug has displayed teratogenic effects in rats. Compared to another drug in the same class, acetazolamide, methazolamide requires a lower dose when administered to patients.
Recently, research has also uncovered a potential new role for this drug, addressing tau toxicity, a theorized cause for diseases such as Alzheimer’s. [1]
References
- ↑ "Carbonic anhydrase inhibition ameliorates tau toxicity via enhanced tau secretion". Nature Chemical Biology 21 (4): 577–587. October 2024. doi:10.1038/s41589-024-01762-7. PMID 39482469.
Further reading
- "In vitro characterization of the erythrocyte distribution of methazolamide: a model of erythrocyte transport and binding kinetics". Journal of Pharmacokinetics and Biopharmaceutics 27 (1): 45–66. February 1999. doi:10.1023/A:1020630712388. PMID 10533697.
- RxList. "Neptazane". http://www.rxlist.com/cgi/generic2/methaz.htm.
- "Stevens-Johnson syndrome induced by methazolamide treatment". Archives of Ophthalmology 115 (4): 550–553. April 1997. doi:10.1001/archopht.1997.01100150552021. PMID 9109770.
- "Effects of oral administration of methazolamide on intraocular pressure and aqueous humor flow rate in clinically normal dogs". American Journal of Veterinary Research 64 (2): 183–187. February 2003. doi:10.2460/ajvr.2003.64.183. PMID 12602587.
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