Chemistry:Paraoxon
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Short description: Chemical compound
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| Formula | C10H14NO6P |
| Molar mass | 275.197 g·mol−1 |
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Paraoxon is a parasympathomimetic which acts as an cholinesterase inhibitor. It is an organophosphate oxon, and the active metabolite of the insecticide parathion. It is also used as an ophthalmological drug against glaucoma. Paraoxon is one of the most potent acetylcholinesterase-inhibiting insecticides available, around 70% as potent as the nerve agent sarin, and so is now rarely used as an insecticide due to the risk of poisoning to humans and other animals. Paraoxon has been used by scientists to study acute and chronic effects of organophosphate intoxication.[1][2] It is easily absorbed through skin, and was allegedly used as an assassination weapon by the apartheid-era South Africa n chemical weapons program Project Coast.[3]
See also
References
- ↑ "Development of status epilepticus, sustained calcium elevations and neuronal injury in a rat survival model of lethal paraoxon intoxication". Neurotoxicology 44: 17–26. September 2014. doi:10.1016/j.neuro.2014.04.006. PMID 24785379.
- ↑ "Chronic behavioral and cognitive deficits in a rat survival model of paraoxon toxicity". Neurotoxicology 44: 352–7. September 2014. doi:10.1016/j.neuro.2014.08.008. PMID 25172410.
- ↑ NTI Country Overviews:South Africa:Chemical Capabilities:Paraoxon
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