Chemistry:Diclofenamide
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| AHFS/Drugs.com | International Drug Names |
| MedlinePlus | a601233 |
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| Pharmacokinetic data | |
| Protein binding | 55% |
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| Chemical and physical data | |
| Formula | C6H6Cl2N2O4S2 |
| Molar mass | 305.14 g·mol−1 |
| 3D model (JSmol) | |
| Melting point | 228.5 °C (443.3 °F) |
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Diclofenamide (or dichlorphenamide) is a sulfonamide and a carbonic anhydrase inhibitor of the meta-disulfamoylbenzene class. Dichlorphenamide as a carbonic anhydrase inhibitor is used for the treatment of acute angle closure glaucoma. While Dichlorphenamide does contain two sulfate groups within the structure, it falls under the class of a first generation carbonic anhydrase Inhibitor.
Uses
Diclofenamide was approved in the United States in 1958 as Daranide to treat glaucoma,[1][2][3] Subsequently, it was found effective in cases of therapy-resistant epilepsy.[4] In 2015, the medication was approved in the US under the name Keveyis as an orphan drug for the treatment of primary hypokalemic and hyperkalemic periodic paralysis.[1][5]
Cost
In 2001, diclofenamide had a U.S. list price of $50 for a bottle of 100 pills, and was approved for glaucoma. Merck discontinued diclofenamide when better glaucoma drugs were developed. In 2010, Sun Pharmaceutical Industries bought the rights.[citation needed] In 2015, the F.D.A. approved it as an orphan drug, with 7-year exclusive marketing rights, for periodic paralysis, which the company estimates affects 5,000 people in the U.S. In 2016, Strongbridge Biopharma acquired Sun, which raised the price to $15,001 for 100 pills. The cost of treatment would range from $109,500 to $219,000 a year. Sun gives the drug free to patients who don't have insurance.[5]
References
- ↑ 1.0 1.1 "Dichlorphenaide (Keveyis) for Periodic Paralysis". The Medical Letter. April 16, 2016. https://secure.medicalletter.org/article-share?a=1492d&p=tml&title=Dichlorphenamide%20(Keveyis)%20for%20Periodic%20Paralysis&cannotaccesstitle=1.
- ↑ International Drug Names: Diclofenamide
- ↑ "Carbonic anhydrase inhibitors and osmotic agents in glaucoma. Carbonic anhydrase inhibitors". The British Journal of Ophthalmology 52 (8): 642–3. August 1968. doi:10.1136/bjo.52.8.642. PMID 5724852.
- ↑ "Diclofenamide in the treatment of therapy-resistant epilepsy". Acta Neurologica Belgica 78 (3): 174–82. 1978. PMID 352085.
- ↑ 5.0 5.1 Johnson, Carolyn Y. (December 18, 2017). "This old drug was free. Now it's $109,500 a year.". Washington Post. https://www.washingtonpost.com/news/wonk/wp/2017/12/18/this-old-drug-was-free-now-its-109500-a-year/.
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