Chemistry:Demecarium bromide
 | |
| Clinical data | |
|---|---|
| Trade names | Humorsol |
| Routes of administration | Topical (ophthalmic solution) |
| ATC code | |
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| DrugBank | |
| ChemSpider | |
| UNII | |
| KEGG | |
| ChEBI | |
| ChEMBL | |
| Chemical and physical data | |
| Formula | C32H52Br2N4O4 |
| Molar mass | 716.600 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
  (what is this?) (verify) | |
Demecarium bromide, trade name Humorsol, is a carbamate parasympathomimetic drug that acts as an acetylcholinesterase inhibitor, and is used as a glaucoma medication. It is applied directly to the eye in order to reduce elevated intraocular pressure associated with glaucoma.[1]
Demecarium causes constriction of the pupil (miosis), which improves the drainage of the fluid in the eye (aqueous humour).[2] As demecarium reversibly inhibits cholinesterase, it can be administered less frequently than other parasympathomimetic drugs, such as carbachol.[3]
Commercially produced demecarium bromide solution, previously sold under the trade name Humorsol,[4] is no longer available,[3] although solutions of demecarium can be compounded.[5]
Use in dogs
When administered with a topical corticosteroid, demecarium can delay the onset of primary glaucoma in dogs.[3] High doses of demecarium may cause organophosphate toxicity, particularly if flea treatments containing organophosphates are administered at the same time.[3]
See also
References
- ↑ "Demecarium bromide". Mosby's dental drug reference (11th ed.). St. Louis, Missouri: Elsevier Mosby. 2014. p. 374. ISBN 978-0-323-16916-5. https://books.google.com/books?id=OcU0AwAAQBAJ&pg=PR548.
- ↑ "Demecarium bromide (Humorsol)". Ophthalmic dictionary and vocabulary builder for eye care professionals (4th ed.). New Delhi: Jaypee Brothers Medical. 2012. p. 103. ISBN 9789350253656. https://books.google.com/books?id=-xnRmiZBzqwC&pg=PA103.
- ↑ 3.0 3.1 3.2 3.3 "Indirect-acting parasympathomimetic agents". Slatter's Fundamentals of Veterinary Ophthalmology (5th ed.). St. Louis, Missouri: Elsevier. 2013. p. 51. ISBN 978-1-4377-2367-0. https://books.google.com/books?id=8QCduRN3zR0C&pg=PA51.
- ↑ Pharmacology for the primary care provider (4th ed.). Elsevier Health Sciences. 2013. p. 174. ISBN 978-0-323-08790-2. https://books.google.com/books?id=8FwdEsvnw8oC&pg=PA174.
- ↑ "Medical Treatment of Primary Canine Glaucoma". The Veterinary Clinics of North America. Small Animal Practice 45 (6): 1235–59, vi. November 2015. doi:10.1016/j.cvsm.2015.06.004. PMID 26319445.
 |  |
