Chemistry:Sphinganine
From HandWiki
Sphinganine is a chemical compound of the sphingolipid class with molecular formula C
18H
39NO
2. Via the action of sphingosine kinase enzymes, it is converted to dihydrosphingosine 1-phosphate (sphinganine 1-phosphate), which has a variety of biological functions.[1]
Sphinganine is one of many sphingoid bases (long-chain bases) besides sphingosine, which are backbones of sphingolipids.[2] It is made by dehydrogenating 3-ketosphinganine, which is produced by condensation reaction of serine with palmitate. It is an intermediate in the biosynthesis of ceramide.[3]
Sphinganine is a diastereomer of safingol.
See also
References
- ↑ "Sphinganine". Lipid Maps Structure Database. https://www.lipidmaps.org/databases/lmsd/LMSP01020001.
- ↑ Merrill, Alfred H. (2025-01-14). "Don't Be Surprised When These Surprise You: Some Infrequently Studied Sphingoid Bases, Metabolites, and Factors That Should Be Kept in Mind During Sphingolipidomic Studies" (in en). International Journal of Molecular Sciences 26 (2): 650. doi:10.3390/ijms26020650. ISSN 1422-0067. PMID 39859363.
- ↑ Abed Rabbo, Muna; Khodour, Yara; Kaguni, Laurie S.; Stiban, Johnny (2021-05-03). "Sphingolipid lysosomal storage diseases: from bench to bedside". Lipids in Health and Disease 20 (1): 44. doi:10.1186/s12944-021-01466-0. ISSN 1476-511X. PMID 33941173.
Further reading
- Qu, Linkai; Wang, Lei; Ji, Hao; Fang, Yimeng; Lei, Pengyu; Zhang, Xingxing; Jin, Libo; Sun, Da et al. (2022-03-01). "Toxic Mechanism and Biological Detoxification of Fumonisins" (in en). Toxins 14 (3): 182. doi:10.3390/toxins14030182. ISSN 2072-6651. PMID 35324679.
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