Medicine:List of largest selling pharmaceutical products

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Current largest selling pharmaceuticals of global market

The top ten best-selling pharmaceuticals of 2025. Sales in billion USD.[1]

Rank Drug Main indication Trade name Sales
1 pembrolizumab oncology Keytruda 31.6
2 tirzepatide diabetes, obesity Mounjaro 23.0
3 semaglutide diabetes, obesity Ozempic 19.2
4 dupilumab atopic dermatitis Dupixent 17.8
5 risankizumab plaque psoriasis Skyrizi 17.6
6 apixaban anticoagulant Eliquis 14.7
7 daratumumab multiple myeloma Darzalex 14.4
8 Bictegravir/emtricitabine/

tenofovir alafenamide

HIV/AIDS Biktarvy 14.3
9 tirzepatide diabetes, obesity Zepbound 13.5
10 semaglutide diabetes, obesity Wegovy 12.0

Historical largest selling pharmaceuticals

2020-2024

2024

The top ten best-selling pharmaceuticals of 2024. Sales in billion USD.[2]

Rank Drug Main indication Trade name Sales
1 pembrolizumab oncology Keytruda 29.5
2 semaglutide diabetes, obesity Ozempic 17.5
3 dupilumab atopic dermatitis Dupixent 14.1
4 Bictegravir/emtricitabine/

tenofovir alafenamide

HIV/AIDS Biktarvy 13.4
5 apixaban anticoagulant Eliquis 13.3
6 risankizumab plaque psoriasis Skyrizi 11.7
7 daratumumab multiple myeloma Darzalex 11.7
8 tirzepatide diabetes, obesity Mounjaro 11.5
9 ustekinumab psoriasis Stelara 10.4
10 elexacaftor/tezacaftor/ivacaftor cystic fibrosis Trikafta 10.2

2023

The top ten best-selling pharmaceuticals of 2023. Sales in billion USD.[3]

Rank Drug Main indication Trade name Sales
1 pembrolizumab oncology Keytruda 25.0
2 adalimumab rheumatoid arthritis Humira 14.4
3 semaglutide diabetes, obesity Ozempic 13.9
4 apixaban anticoagulant Eliquis 12.2
5 Bictegravir/emtricitabine/

tenofovir alafenamide

HIV/AIDS Biktarvy 11.9
6 dupilumab atopic dermatitis Dupixent 11.6
7 Pfizer–BioNTech COVID-19 vaccine COVID-19 vaccination Comirnaty 11.2
8 ustekinumab psoriasis Stelara 10.9
9 daratumumab multiple myeloma Darzalex 9.7
10 nivolumab oncology Opdivo 9.0

2022

The top ten best-selling pharmaceuticals of 2022. Sales in billion USD.[4]

Rank Drug Main indication Trade name Sales
1 Pfizer–BioNTech COVID-19 vaccine COVID-19 vaccination Comirnaty 40.8
2 Moderna COVID-19 vaccine COVID-19 vaccination Spikevax 21.8
3 adalimumab rheumatoid arthritis Humira 21.6
4 pembrolizumab oncology Keytruda 21.0
5 nirmatrelvir/ritonavir COVID-19 Paxlovid 19.0
6 apixaban anticoagulant Eliquis 11.8
7 Bictegravir/emtricitabine/

tenofovir alafenamide

HIV/AIDS Biktarvy 10.4
8 aflibercept macular degeneration,

colorectal cancer

Eylea 10.3
9 ustekinumab psoriasis Stelara 10.1
10 lenalidomide oncology Revlimid 10.0

2021

The top ten best-selling pharmaceuticals of 2021. Sales in billion USD.[5]

Rank Drug Main indication Trade name Sales
1 Pfizer–BioNTech COVID-19 vaccine COVID-19 vaccination Comirnaty 36.9
2 adalimumab rheumatoid arthritis Humira 20.7
3 Moderna COVID-19 vaccine COVID-19 vaccination Spikevax 17.7
4 pembrolizumab oncology Keytruda 17.2
5 lenalidomide oncology Revlimid 12.8
6 apixaban anticoagulant Eliquis 10.8
7 ustekinumab psoriasis Stelara 9.1
8 Bictegravir/emtricitabine/

tenofovir alafenamide

HIV/AIDS Biktarvy 8.6
9 nivolumab oncology Opvido 7.6
10 dulaglutide diabetes Trulicity 6.5

2020

The top ten best-selling pharmaceuticals of 2020. Sales in billion USD.[6]

Rank Drug Main indication Trade name Sales
1 adalimumab rheumatoid arthritis Humira 20.4
2 pembrolizumab oncology Keytruda 14.4
3 lenalidomide oncology Revlimid 12.2
4 apixaban anticoagulant Eliquis 9.2
5 aflibercept macular degeneration,

colorectal cancer

Eylea 8.4
6 ustekinumab psoriasis Stelara 7.9
7 nivolumab oncology Opvido 7.9
8 ibrutinib oncology Imbruvica 7.6
9 Bictegravir/emtricitabine/

tenofovir alafenamide

HIV/AIDS Biktarvy 7.3
10 rivaroxaban anticoagulant Xarelto 6.9

2012-2019

Top five best-selling pharmaceuticals 2012-2019.

2019

Source:[7]

  1. adalimumab
  2. pembrolizumab
  3. lenalidomide
  4. apixaban
  5. nivolumab

2018

Source:[8]

  1. adalimumab
  2. lenalidomide
  3. pembrolizumab
  4. trastuzumab
  5. bevacizumab

2017

Source:[9]

  1. adalimumab
  2. lenalidomide
  3. rituximab
  4. trastuzumab
  5. bevacizumab

2016

Source:[10]

  1. adalimumab
  2. ledipasvir
  3. etanercept
  4. rituximab
  5. infliximab

2015

Source:[11][12]

  1. adalimumab
  2. ledipasvir
  3. etanercept
  4. infliximab
  5. rituximab

2014

Source:[13]

  1. adalimumab
  2. sofosbuvir
  3. infliximab
  4. rituximab
  5. etanercept

2013

Source:[14]

  1. aripiprazole
  2. adalimumab
  3. esomeprazole
  4. rosuvastatin
  5. etanercept

2012

Source:[15]

  1. adalimumab
  2. infliximab
  3. etanercept
  4. fluticasone/salmeterol
  5. rituximab

2000-2011

Cumulative top ten best-selling pharmaceuticals between 2000 and 2011. Sales in billion USD[16]

Rank Drug Main indication Trade name Sales
1 atorvastatin cholesterol Lipitor 121.4
2 clopidogrel heart disease Plavix 74.6
3 fluticasone/salmeterol asthma Advair 58.8
4 olanzapine schizophrenia,

bipolar disorder

Zyprexa 50.4
5 etanercept rheumatoid arthritis Enbrel 45.2
6 esomeprazole gastrointestinal disorders Nexium 44.3
7 montelukast asthma Singulair 38.5
7 quetiapine fumarate schizophrenia,

bipolar disorder

Seroquel 36.7
9 enoxaparin anticoagulant Lovenox 33.1
10 adalimumab rheumatoid arthritis Humira 32.0

See also

References

  1. ↑ Verdin, Paul (2026-03-06). "Top companies and drugs by sales in 2025" (in en). Nature Reviews Drug Discovery 25 (4): 258–258. doi:10.1038/d41573-026-00041-5. ISSN 1474-1784. https://www.nature.com/articles/d41573-026-00041-5. 
  2. ↑ Verdin, Paul (2025-03-12). "Top companies and drugs by sales in 2024" (in en). Nature Reviews Drug Discovery 24 (4): 240–240. doi:10.1038/d41573-025-00049-3. ISSN 1474-1784. https://www.nature.com/articles/d41573-025-00049-3. 
  3. ↑ Verdin, Paul (2024-03-08). "Top companies and drugs by sales in 2023" (in en). Nature Reviews Drug Discovery 23 (4): 240–240. doi:10.1038/d41573-024-00041-3. https://www.nature.com/articles/d41573-024-00041-3. 
  4. ↑ Urquhart, Lisa (2023-03-07). "Top companies and drugs by sales in 2022" (in en). Nature Reviews Drug Discovery 22 (4): 260–260. doi:10.1038/d41573-023-00039-3. https://www.nature.com/articles/d41573-023-00039-3. 
  5. ↑ Urquhart, Lisa (2022-03-11). "Top companies and drugs by sales in 2021" (in en). Nature Reviews Drug Discovery 21 (4): 251–251. doi:10.1038/d41573-022-00047-9. https://www.nature.com/articles/d41573-022-00047-9. 
  6. ↑ Urquhart, Lisa (2021-03-16). "Top companies and drugs by sales in 2020" (in en). Nature Reviews Drug Discovery 20 (4): 253–253. doi:10.1038/d41573-021-00050-6. https://www.nature.com/articles/d41573-021-00050-6. 
  7. ↑ Urquhart, Lisa (2020-03-13). "Top companies and drugs by sales in 2019" (in en). Nature Reviews Drug Discovery 19 (4): 228–228. doi:10.1038/d41573-020-00047-7. https://www.nature.com/articles/d41573-020-00047-7. 
  8. ↑ Urquhart, Lisa (2019-03-12). "Top drugs and companies by sales in 2018" (in en). Nature Reviews Drug Discovery 18 (4): 245–245. doi:10.1038/d41573-019-00049-0. https://www.nature.com/articles/d41573-019-00049-0. 
  9. ↑ Urquhart, Lisa (2018-04-01). "Top drugs and companies by sales in 2017" (in en). Nature Reviews Drug Discovery 17 (4): 232–232. doi:10.1038/nrd.2018.42. ISSN 1474-1784. https://www.nature.com/articles/nrd.2018.42. 
  10. ↑ Philippidis, Alex (2017-03-06). "The Top 15 Best-Selling Drugs of 2016" (in en-US). https://www.genengnews.com/a-lists/the-top-15-best-selling-drugs-of-2016/. 
  11. ↑ "The Top 15 Best-Selling Drugs of 2016". 6 March 2017. https://www.genengnews.com/a-lists/the-top-15-best-selling-drugs-of-2016/. 
  12. ↑ "Top drugs by sales revenue in 2015: Who sold the biggest blockbuster drugs?". March 10, 2016. http://www.pharmacompass.com/radio-compass-blog/top-drugs-by-sales-revenue-in-2015-who-sold-the-biggest-blockbuster-drugs. 
  13. ↑ Philippidis, Alex (2015-02-23). "The Top 25 Best-Selling Drugs of 2014" (in en-US). https://www.genengnews.com/a-lists/the-top-25-best-selling-drugs-of-2014/. 
  14. ↑ Drugs.com U.S. Pharmaceutical Sales - Q4 2013, updated Feb. 2014
  15. ↑ Philippidis, Alex (2013-03-05). "Top 20 Best-Selling Drugs of 2012" (in en-US). https://www.genengnews.com/a-lists/top-20-best-selling-drugs-of-2012/. 
  16. ↑ Philippidis, Alex (2012-11-06). "Top 10 Best-Selling Drugs of the 21st Century" (in en-US). https://www.genengnews.com/a-lists/top-10-best-selling-drugs-of-the-21st-century/. 



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