Unsolved:Aldehyde-stabilized cryopreservation
Aldehyde-stabilized cryopreservation is a new technique for cryopreservation first demonstrated in 2016 by Robert L. McIntyre and Gregory Fahy at the cryobiology research company 21st Century Medicine, Inc. This technique use a particular implementation of fixation and vitrification that can successfully preserve a rabbit brain in "near perfect" condition at −135 °C, with the cell membranes, synapses, and intracellular structures intact in electron micrographs.[1] The technique has finally won Small Animal Brain Preservation Prize of the Brain Preservation Foundation.[2][3] The cryopreserved brain have rewarmed and found there are no serious degraduation occurred, the brain structure under electron microscopic evaluation after rewarm still preserve well.[4][5] Although these technique still yet to successfully revival of a cryopreserved brain, some researcher see this technique provide a better possible research directions in future.[6]
See also
References
- ↑ "Aldehyde-stabilized cryopreservation". Cryobiology 71 (3): 448–458. December 2015. doi:10.1016/j.cryobiol.2015.09.003. PMID 26408851.
- ↑ Claire Maldarelli (9 February 2016). "Researchers Have Preserved an Entire Rabbit Brain". Popular Science. http://www.popsci.com/researchers-have-preserved-an-entire-rabbit-brain.
- ↑ Michael Shermer (1 February 2016). "Can Our Minds Live Forever?". Scientific American. http://www.scientificamerican.com/article/can-our-minds-live-forever/.
- ↑ "21st Century Medicine's Aldehyde-Stabilized Cryopreservation". Brain Preservation Foundation. 16 September 2015. https://www.brainpreservation.org/21cm-aldehyde-stabilized-cryopreservation-eval-page/.
- ↑ "Aldehyde-Stabilized Cryopreservation Wins Final Phase of Brain Preservation Prize". PRWeb. https://www.prweb.com/releases/2018/03/prweb15276833.htm.
- ↑ Ekpo, Marlene Davis; Boafo, George Frimpong; Gambo, Suleiman Shafiu; Hu, Yuying; Liu, Xiangjian; Xie, Jingxian; Tan, Songwen (2022-06-09). "Cryopreservation of Animals and Cryonics: Current Technical Progress, Difficulties and Possible Research Directions". Frontiers in Veterinary Science (Frontiers) 9: 877163. doi:10.3389/fvets.2022.877163. PMID 35754544.
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