Biology:ADAM18
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Disintegrin and metalloproteinase domain-containing protein 18 is an enzyme that in humans is encoded by the ADAM18 gene.[1][2]
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a sperm surface protein.[2]
References
- ↑ "Human tMDC III: a sperm protein with a potential role in oocyte recognition". Mol Hum Reprod 8 (9): 817–22. Aug 2002. doi:10.1093/molehr/8.9.817. PMID 12200459.
- ↑ 2.0 2.1 "Entrez Gene: ADAM18 ADAM metallopeptidase domain 18". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8749.
Further reading
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. 2003. doi:10.1101/gr.1293003. PMID 12975309.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Identification of four novel ADAMs with potential roles in spermatogenesis and fertilization.". Gene 234 (2): 227–37. 1999. doi:10.1016/S0378-1119(99)00208-5. PMID 10395895.
- "Macaque MDC family of proteins: sequence analysis, tissue distribution and processing in the male reproductive tract.". Mol. Hum. Reprod. 4 (5): 429–37. 1998. doi:10.1093/molehr/4.5.429. PMID 9665629.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
External links
- The MEROPS online database for peptidases and their inhibitors: M12.957
- Human ADAM18 genome location and ADAM18 gene details page in the UCSC Genome Browser.
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