Biology:FUT2
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Short description: Protein-coding gene in humans
 Generic protein structure example |
Galactoside 2-alpha-L-fucosyltransferase 2 is an enzyme that in humans is encoded by the FUT2 gene.[1][2] It affects the secretor status of ABO antigens.[3]
Approximately 20% of Caucasians are non-secretors due to the G428A (rs601338) and C571T (rs492602?) nonsense mutations in FUT2 and therefore have strong although not absolute protection from the norovirus GII.4.[citation needed]
References
- ↑ "The human chromosome 19 linkage group FUT1 (H), FUT2 (SE), LE, LU, PEPD, C3, APOC2, D19S7 and D19S9". Ann Hum Genet 55 (Pt 3): 225–33. Feb 1992. doi:10.1111/j.1469-1809.1991.tb00417.x. PMID 1763885.
- ↑ "Entrez Gene: FUT2 fucosyltransferase 2 (secretor status included)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2524.
- ↑ "Names for H (ISBT 018) Blood Group Alleles". http://www.isbtweb.org/fileadmin/user_upload/Working_parties/WP_on_Red_Cell_Immunogenetics_and/018_H_Alleles_v5.1_170221.pdf.
Further reading
- Reguigne-Arnould I; Couillin P; Mollicone R et al. (1995). "Relative positions of two clusters of human alpha-L-fucosyltransferases in 19q (FUT1-FUT2) and 19p (FUT6-FUT3-FUT5) within the microsatellite genetic map of chromosome 19". Cytogenet. Cell Genet. 71 (2): 158–62. doi:10.1159/000134098. PMID 7656588.
- Rouquier S; Lowe JB; Kelly RJ et al. (1995). "Molecular cloning of a human genomic region containing the H blood group alpha(1,2)fucosyltransferase gene and two H locus-related DNA restriction fragments. Isolation of a candidate for the human Secretor blood group locus". J. Biol. Chem. 270 (9): 4632–9. doi:10.1074/jbc.270.9.4632. PMID 7876234.
- Kelly RJ; Rouquier S; Giorgi D et al. (1995). "Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransferase gene (FUT2). Homozygosity for an enzyme-inactivating nonsense mutation commonly correlates with the non-secretor phenotype". J. Biol. Chem. 270 (9): 4640–9. doi:10.1074/jbc.270.9.4640. PMID 7876235.
- Kudo T; Iwasaki H; Nishihara S et al. (1996). "Molecular genetic analysis of the human Lewis histo-blood group system. II. Secretor gene inactivation by a novel single missense mutation A385T in Japanese nonsecretor individuals". J. Biol. Chem. 271 (16): 9830–7. doi:10.1074/jbc.271.16.9830. PMID 8621666.
- "Molecular basis for secretor type alpha(1,2)-fucosyltransferase gene deficiency in a Japanese population: a fusion gene generated by unequal crossover responsible for the enzyme deficiency". Am. J. Hum. Genet. 59 (2): 343–50. 1996. PMID 8755920.
- "Structure and expression of the gene encoding secretor-type galactoside 2-alpha-L-fucosyltransferase (FUT2)". Eur. J. Biochem. 246 (3): 750–5. 1997. doi:10.1111/j.1432-1033.1997.t01-1-00750.x. PMID 9219535.
- Koda Y; Soejima M; Johnson PH et al. (1997). "Missense mutation of FUT1 and deletion of FUT2 are responsible for Indian Bombay phenotype of ABO blood group system". Biochem. Biophys. Res. Commun. 238 (1): 21–5. doi:10.1006/bbrc.1997.7232. PMID 9299444.
- Liu Y; Koda Y; Soejima M et al. (1998). "Extensive polymorphism of the FUT2 gene in an African (Xhosa) population of South Africa". Hum. Genet. 103 (2): 204–10. doi:10.1007/s004390050808. PMID 9760207.
- "Molecular cloning, genomic mapping, and expression of two secretor blood group alpha (1,2)fucosyltransferase genes differentially regulated in mouse uterine epithelium and gastrointestinal tract". J. Biol. Chem. 276 (26): 23748–56. 2001. doi:10.1074/jbc.M100735200. PMID 11323419.
- "Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism". J. Biol. Chem. 277 (5): 3168–75. 2002. doi:10.1074/jbc.M107927200. PMID 11698403.
- Milland J; Russell SM; Dodson HC et al. (2002). "The cytoplasmic tail of alpha 1,3-galactosyltransferase inhibits Golgi localization of the full-length enzyme". J. Biol. Chem. 277 (12): 10374–8. doi:10.1074/jbc.M111799200. PMID 11777923.
- Chang JG; Ko YC; Lee JC et al. (2002). "Molecular analysis of mutations and polymorphisms of the Lewis secretor type alpha(1,2)-fucosyltransferase gene reveals that Taiwan aborigines are of Austronesian derivation". J. Hum. Genet. 47 (2): 60–5. doi:10.1007/s100380200001. PMID 11916003.
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- Lindesmith L; Moe C; Marionneau S et al. (2003). "Human susceptibility and resistance to Norwalk virus infection". Nat. Med. 9 (5): 548–53. doi:10.1038/nm860. PMID 12692541.
- Guo ZH; Xiang D; Zhu ZY et al. (2004). "[Analysis on FUT1 and FUT2 gene of 10 para-Bombay individuals in China]". Zhonghua Yi Xue Yi Chuan Xue Za Zhi 21 (5): 417–21. PMID 15476160.
- Chen DP; Tseng CP; Wang WT et al. (2005). "Two prevalent h alleles in para-Bombay haplotypes among 250,000 Taiwanese". Ann. Clin. Lab. Sci. 34 (3): 314–8. PMID 15487706.
- "A novel tetrameric short tandem repeat located in the 3' flanking region of the human ABO-secretor gene (FUT2) and association between FUT2 and FUT2/01 loci". Hum. Biol. 76 (5): 789–95. 2005. doi:10.1353/hub.2005.0008. PMID 15757249.
- Madjd Z; Parsons T; Watson NF et al. (2006). "High expression of Lewis y/b antigens is associated with decreased survival in lymph node negative breast carcinomas". Breast Cancer Res. 7 (5): R780–7. doi:10.1186/bcr1305. PMID 16168124.
- Kimura K; Wakamatsu A; Suzuki Y et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
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