Biology:Uracil phosphoribosyltransferase
From HandWiki
Short description: Class of enzymes
| Uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae) | |
|---|---|
| Identifiers | |
| Symbol | UPRT |
| NCBI gene | 139596 |
| HGNC | 28334 |
| RefSeq | NM_145052 |
| UniProt | Q96BW1 |
| Other data | |
| Locus | Chr. X q13.3 |
| Uridine phosphorylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.4.2.9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Uracil phosphoribosyltransferase is an enzyme which interconverts uridine monophosphate with uracil and phosphoribosyl pyrophosphate. In the forward direction shown, pyrophosphoric acid is added to the ribose sugar unit to cleave off the attached heterocycle.[1][2]
- REDIRECT Template:Chemical reaction
This protein is thought to use the morpheein model of allosteric regulation.[3]
References
- ↑ Enzyme 2.4.2.9 at KEGG Pathway Database.
- ↑ Crawford, I; Kornberg, A; Simms, ES (1957). "Conversion of uracil and orotate to uridine 5'-phosphate by enzymes in lactobacilli" (pdf). Journal of Biological Chemistry. PMID 13438895. https://www.jbc.org/article/S0021-9258(18)70892-2/pdf.
- ↑ "Dynamic dissociating homo-oligomers and the control of protein function". Archives of Biochemistry and Biophysics 519 (2): 131–43. March 2012. doi:10.1016/j.abb.2011.11.020. PMID 22182754.
External links
- Uracil+phosphoribosyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)
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