Biology:Arabinosyltransferase
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Short description: Class of enzymes
| Arabinosyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Arabinose_trans | ||||||||
| Pfam | PF04602 | ||||||||
| Pfam clan | CL0111 | ||||||||
| InterPro | IPR007680 | ||||||||
| CAZy | GT53 | ||||||||
| |||||||||
An arabinosyltransferase is a transferase enzyme acting upon arabinose.[1] This enzyme is involved in polymerisation of arabinogalactan (an essential component of the mycobacterial cell wall). Mycobacterially, the more precise term is arabinofuranosyltransferase, since the arabinose residues occur only in a furanose form.
This enzyme has important clinical applications as it is believed to be the target of the antimycobacterial drug ethambutol.[2]
References
- ↑ "Reconstitution of functional mycobacterial arabinosyltransferase AftC proteoliposome and assessment of decaprenylphosphorylarabinose analogues as arabinofuranosyl donors". ACS Chem. Biol. 6 (8): 819–28. 2011. doi:10.1021/cb200091m. PMID 21595486.
- ↑ "The embAB genes of Mycobacterium avium encode an arabinosyl transferase involved in cell wall arabinan biosynthesis that is the target for the antimycobacterial drug ethambutol". Proc. Natl. Acad. Sci. U.S.A. 93 (21): 11919–24. October 1996. doi:10.1073/pnas.93.21.11919. PMID 8876238. Bibcode: 1996PNAS...9311919B.
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