Biology:GDP-fucose protein O-fucosyltransferase 2
From HandWiki
Short description: Mammalian protein found in Homo sapiens
 Generic protein structure example |
GDP-fucose protein O-fucosyltransferase 2 (POFUT2) is an enzyme responsible for adding fucose sugars in O linkage to serine or threonine residues in Thrombospondin repeats.[1] The protein is an inverting glycosyltransferase, which means that the enzyme uses GDP-β-L-fucose as a donor substrate and transfers the fucose in O linkage to the protein producing fucose-α-O-serine/threonine.
Almost all glycosyltransferases reside in the Golgi apparatus. However, POFUT2 as well as the related enzyme POFUT1 have recently been shown to reside in the endoplasmic reticulum.
The malaria parasite Plasmodium falciparum requires POFUT2 for efficient transmission to mosquitoes and infection of human liver cells.[2]
See also
References
- ↑ GDP-fucose protein O-fucosyltransferase 2, The Universal Protein Resource
- ↑ "Protein O-fucosylation in Plasmodium falciparum ensures efficient infection of mosquito and vertebrate hosts". Nature Communications 8 (1): 561. September 2017. doi:10.1038/s41467-017-00571-y. PMID 28916755. Bibcode: 2017NatCo...8..561L.
External links
- POFUT2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
 |  |
