Biology:Dolichyl-P-Man:Man7GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase
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| Dolichyl-P-Man:Man7GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.4.1.260 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Dolichyl-P-Man:Man7GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase (EC 2.4.1.260, ALG12, ALG12 mannosyltransferase, ALG12 alpha1,6mannosyltransferase, dolichyl-P-mannose:Man7GlcNAc2-PP-dolichyl mannosyltransferase, dolichyl-P-Man:Man7GlcNAc2-PP-dolichyl alpha6-mannosyltransferase, EBS4, Dol-P-Man:Man7GlcNAc2-PP-Dol alpha-1,6-mannosyltransferase) is an enzyme with systematic name dolichyl beta-D-mannosyl phosphate:D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol alpha-1,6-mannosyltransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction
- dolichyl beta-D-mannosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol [math]\displaystyle{ \rightleftharpoons }[/math] D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate
References
- ↑ "ALG9 mannosyltransferase is involved in two different steps of lipid-linked oligosaccharide biosynthesis". Glycobiology 15 (11): 1156–63. November 2005. doi:10.1093/glycob/cwj002. PMID 15987956.
- ↑ "Mutations of an alpha1,6 mannosyltransferase inhibit endoplasmic reticulum-associated degradation of defective brassinosteroid receptors in Arabidopsis". The Plant Cell 21 (12): 3792–802. December 2009. doi:10.1105/tpc.109.070284. PMID 20023196.
- ↑ "The Saccharomyces cerevisiae alg12delta mutant reveals a role for the middle-arm alpha1,2Man- and upper-arm alpha1,2Manalpha1,6Man- residues of Glc3Man9GlcNAc2-PP-Dol in regulating glycoprotein glycan processing in the endoplasmic reticulum and Golgi apparatus". Glycobiology 12 (11): 749–62. November 2002. doi:10.1093/glycob/cwf082. PMID 12460943.
- ↑ "ALG12 mannosyltransferase defect in congenital disorder of glycosylation type lg". Human Molecular Genetics 11 (19): 2331–9. September 2002. doi:10.1093/hmg/11.19.2331. PMID 12217961.
External links
- Dolichyl-P-Man:Man7GlcNAc2-PP-dolichol+alpha-1,6-mannosyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)
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