Biology:ADCY1
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Adenylyl cyclase type 1 is an enzyme that in humans is encoded by the ADCY1 gene.[1][2]
This gene encodes a form of adenylyl cyclase expressed in the brain. A similar protein in mice is involved in pattern formation of the brain.[2]
Function
ADCY1 is a calmodulin-sensitive adenylyl cyclase. In terms of function, It may be involved in regulatory processes in the central nervous system; specifically, it may play a role in memory acquisition and learning. It is inhibited by the G protein beta and gamma subunit complex.[3]
References
- ↑ "Cloning, chromosomal mapping, and expression of human fetal brain type I adenylyl cyclase". Genomics 16 (2): 473–8. May 1993. doi:10.1006/geno.1993.1213. PMID 8314585.
- ↑ 2.0 2.1 "Entrez Gene: ADCY1 adenylyl cyclase 1 (brain)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=107.
- ↑ "Gene Cards: ADCY1 Gene". https://www.genecards.org/cgi-bin/carddisp.pl?gene=ADCY1.
External links
- Human ADCY1 genome location and ADCY1 gene details page in the UCSC Genome Browser.
Further reading
- "G alpha i-G alpha s chimeras define the function of alpha chain domains in control of G protein activation and beta gamma subunit complex interactions". Cell 63 (4): 697–706. Nov 1990. doi:10.1016/0092-8674(90)90136-3. PMID 2121366.
- "Mammalian adenylyl cyclase family members are randomly located on different chromosomes". Human Genetics 94 (5): 527–9. Nov 1994. doi:10.1007/BF00211020. PMID 7959689.
- "Interaction of the two cytosolic domains of mammalian adenylyl cyclase". Proceedings of the National Academy of Sciences of the United States of America 93 (13): 6621–5. Jun 1996. doi:10.1073/pnas.93.13.6621. PMID 8692867. Bibcode: 1996PNAS...93.6621W.
- "Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1". Pflügers Archiv 437 (4): 538–46. Mar 1999. doi:10.1007/s004240050815. PMID 10089566.
- "HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones". AIDS 14 (6): 629–36. Apr 2000. doi:10.1097/00002030-200004140-00001. PMID 10807185.
- "gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression". The Journal of Allergy and Clinical Immunology 105 (5): 975–82. May 2000. doi:10.1067/mai.2000.105315. PMID 10808179.
- "Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures". Journal of Neurochemistry 77 (2): 399–407. Apr 2001. doi:10.1046/j.1471-4159.2001.00249.x. PMID 11299302.
- "Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland". The Journal of Clinical Endocrinology and Metabolism 86 (9): 4495–503. Sep 2001. doi:10.1210/jcem.86.9.7837. PMID 11549699.
- "Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons". Journal of Virology 76 (7): 3179–88. Apr 2002. doi:10.1128/JVI.76.7.3179-3188.2002. PMID 11884542.
- "Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms". Journal of Receptor and Signal Transduction Research 22 (1–4): 79–110. 2003. doi:10.1081/RRS-120014589. PMID 12503609.
- "Tissue transglutaminase directly regulates adenylyl cyclase resulting in enhanced cAMP-response element-binding protein (CREB) activation". The Journal of Biological Chemistry 278 (29): 26838–43. Jul 2003. doi:10.1074/jbc.M303683200. PMID 12743114.
- "Overexpression of type-1 adenylyl cyclase in mouse forebrain enhances recognition memory and LTP". Nature Neuroscience 7 (6): 635–42. Jun 2004. doi:10.1038/nn1248. PMID 15133516.
- "Using molecular tools to dissect the role of Galphas in sensitization of AC1". Molecular Pharmacology 66 (6): 1617–24. Dec 2004. doi:10.1124/mol.104.000166. PMID 15361543.
- "Interaction of the amyloid precursor like protein 1 with the alpha2A-adrenergic receptor increases agonist-mediated inhibition of adenylate cyclase". Cellular Signalling 18 (10): 1748–57. Oct 2006. doi:10.1016/j.cellsig.2006.01.017. PMID 16531006.
- "Calcium-mediated, purinergic stimulation and polarized localization of calcium-sensitive adenylyl cyclase isoforms in human airway epithelia". FEBS Letters 581 (17): 3241–6. Jul 2007. doi:10.1016/j.febslet.2007.06.015. PMID 17586501.
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