Medicine:Trichomoniasis

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Trichomoniasis
Trichomonas May-Grünwald staining.jpg
Micrograph showing Trichomonas vaginalis using May-Grünwald staining
SpecialtyGynecology Microbiology Infectious diseases
SymptomsItching in the genital area, bad smelling thin vaginal discharge, burning with urination, pain with sex[1][2]
Usual onset5 to 28 days after exposure[1]
CausesTrichomonas vaginalis (typically sexually transmitted)[2][1]
Diagnostic methodFinding the parasite in vaginal fluid, microbial culture, testing for the parasites DNA[1]
PreventionNot having sex, using condoms, not douching[1]
MedicationAntibiotics (metronidazole or tinidazole)[1]
Frequency122 million (2015)[3]

Trichomoniasis (trich) is an infectious disease caused by the parasite Trichomonas vaginalis.[2] About 70% of affected people do not have symptoms when infected.[2] When symptoms occur, they typically begin 5 to 28 days after exposure.[1] Symptoms can include itching in the genital area, a bad smelling thin vaginal discharge, burning with urination, and pain with sex.[1][2] Having trichomoniasis increases the risk of getting HIV/AIDS.[1] It may also cause complications during pregnancy.[1]

Trichomoniasis is a sexually transmitted infection (STI) which is most often spread through vaginal, oral, or anal sex.[1] It can also spread through genital touching (manual sex).[1] People who are infected may spread the disease even when symptoms are not present.[2] Diagnosis is by finding the parasite in the vaginal fluid using a microscope, culturing the vaginal fluid or urine, or testing for the parasite's DNA.[1] If present, other STIs should be tested for.[1]

Methods of prevention include not having sex, using condoms, not douching, and being tested for STIs before having sex with a new partner.[1] Although not caused by a bacterium, trichomoniasis can be cured with certain antibiotics (metronidazole, tinidazole, secnidazole).[1] Sexual partners should also be treated.[1] About 20% of people get infected again within three months of treatment.[2]

There were about 122 million new cases of trichomoniasis in 2015.[3] In the United States, there are about 2 million women affected.[1] It occurs more often in women than men.[1] Trichomonas vaginalis was first identified in 1836 by Alfred Donné.[4] It was first recognized as causing this disease in 1916.[5]

Signs and symptoms

File:Trichomonas vaginalis.webm Most people infected with Trichomonas vaginalis do not have any symptoms and can be undetected for years.[6] Symptoms experienced include pain, burning or itching in the penis, urethra (urethritis), or vagina (vaginitis). Discomfort for both sexes may increase during intercourse and urination. For women there may also be a yellow-green, itchy, frothy, foul-smelling ("fishy" smell) vaginal discharge. In rare cases, lower abdominal pain can occur. Symptoms usually appear within 5 to 28 days of exposure.[7] Sometimes trichomoniasis can be confused with chlamydia because the symptoms are similar.[8]

Complications

Trichomoniasis is linked to several serious complications.

  • Trichomoniasis is associated with increased risk of transmission and infection of HIV.[9][10]
  • Trichomoniasis may cause a woman to deliver a low-birth-weight or premature infant.[9]
  • The role of Trichomonas infection in causing cervical cancer is unclear, although trichomonas infection may be associated with co-infection with high-risk strains of HPV.[11]
  • T. vaginalis infection in males has been found to cause asymptomatic urethritis and prostatitis. In the prostate, it may create chronic inflammation that may eventually lead to prostate cancer.[12][13]

Causes

Lifecycle of Trichomonas

The human genital tract is the only reservoir for this species. Trichomonas is transmitted through sexual or genital contact.[14]

The single-celled protozoan produces mechanical stress on host cells and then ingests cell fragments after cell death.[15]

Genetic sequence

A draft sequence of the Trichomonas genome was published on January 12, 2007, in the journal Science confirming that the genome has at least 26,000 genes, a similar number to the human genome. An additional approximately 34,000 unconfirmed genes, including thousands that are part of potentially transposable elements, brings the gene content to well over 60,000.[16]

Diagnosis

There are three main ways to test for trichomoniasis.

  • The first is known as saline microscopy. This is the most commonly used method and requires an endocervical, vaginal, or penile swab specimen for examination under a microscope.[17] The presence of one or multiple trichomonads constitutes a positive result. This method is cheap but has a low sensitivity (60–70%) often due to an inadequate sample, resulting in false negatives.[18][19]
  • The second diagnostic method is culture, which has historically been the "gold standard" in infectious disease diagnosis. Trichomonas vaginalis culture tests are relatively cheap; however, sensitivity is still somewhat low (70–89%).[20]
  • The third method includes the nucleic acid amplification tests (NAATs) which are more sensitive.[20] These tests are more costly than microscopy and culture, and are highly sensitive (80–90%).[21]

Prevention

Use of male condoms or female condoms may help prevent the spread of trichomoniasis,[22] although careful studies have never been done that focus on how to prevent this infection. Infection with trichomoniasis through water is unlikely because Trichomonas vaginalis dies in water after 45–60 minutes, in thermal water after 30 minutes to 3 hours and in diluted urine after 5–6 hours.[23]

Currently there are no routine standard screening requirements for the general U.S. population receiving family planning or STI testing.[24][25] The Centers for Disease Control and Prevention (CDC) recommends trichomoniasis testing for females with vaginal discharge[26] and can be considered for females at higher risk for infection or of HIV-positive serostatus.[24]

The advent of new, highly specific and sensitive trichomoniasis tests present opportunities for new screening protocols for both men and women.[24][27] Careful planning, discussion, and research are required to determine the cost-efficiency and most beneficial use of these new tests for the diagnosis and treatment of trichomoniasis in the U.S., which can lead to better prevention efforts.[24][27]

A number of strategies have been found to improve follow-up for STI testing including email and text messaging as reminders of appointments.[28]

Screening

Evidence from randomized controlled trials for screening pregnant women who do not have symptoms for infection with trichomoniasis and treating women who test positive for the infection have not consistently shown a reduced risk of preterm birth.[29][30] Further studies are needed to verify this result and determine the best method of screening. In the US, screening of pregnant women without any symptoms is only recommended in those with HIV as Trichomonas infection is associated with increased risk of transmitting HIV to the fetus.[31]

Treatment

Treatment for both pregnant and non-pregnant women is usually with metronidazole,[32] by mouth once.[31] Caution should be used in pregnancy, especially in the first trimester.[33] Sexual partners, even if they have no symptoms, should also be treated.[23] Single oral dose of nitroimidazole is sufficient to kill the parasites.[34]

For 95–97% of cases, infection is resolved after one dose of metronidazole.[26][35] Studies suggest that 4–5% of trichomonas cases are resistant to metronidazole, which may account for some "repeat" cases.[33][9] Without treatment, trichomoniasis can persist for months to years in women, and is thought to improve without treatment in men.[9] Women living with HIV infection have better cure rates if treated for seven days rather than with one dose.[31][36]

Topical treatments are less effective than oral antibiotics due to Skene's gland and other genitourinary structures acting as a reservoir.[37]

Epidemiology

There were about 58 million cases of trichomoniasis in 2013.[38] It is more common in females (2.7%) than males (1.4%).[39] It is the most common non-viral STI in the U.S., with an estimated 3.7 million prevalent cases and 1.1 million new cases per year.[40][41] It is estimated that 3% of the general U.S. population is infected,[21][42] and 7.5–32% of moderate-to-high risk (including incarcerated) populations.[43][44]

See also

  • Trichomonas gallinae is a related pathogen of birds

References

  1. ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 1.14 1.15 1.16 1.17 1.18 "Trichomoniasis". August 31, 2015. http://www.womenshealth.gov/publications/our-publications/fact-sheet/trichomoniasis.html#. 
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 "Trichomoniasis - CDC Fact Sheet". November 17, 2015. https://www.cdc.gov/std/trichomonas/stdfact-trichomoniasis.htm. 
  3. ↑ 3.0 3.1 "Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015". Lancet 388 (10053): 1545–1602. October 2016. doi:10.1016/S0140-6736(16)31678-6. PMID 27733282. 
  4. ↑ Wiser, Mark (2010). Protozoa and Human Disease. Garland Science. p. 60. ISBN 9781136738166. https://books.google.com/books?id=zjEWBAAAQBAJ&pg=PA60. 
  5. ↑ Pearson, Richard D. (2001). Principles and Practice of Clinical Parasitology.. Chichester: John Wiley & Sons. p. 243. ISBN 9780470851722. https://books.google.com/books?id=_BcNvch0jhAC&pg=PA243. 
  6. ↑ "STD Facts - Trichomoniasis". cdc.gov. https://www.cdc.gov/std/trichomonas/stdfact-trichomoniasis.htm. 
  7. ↑ Trichomoniasis symptoms . cdc.gov
  8. ↑ "Can Trichomoniasis Be Confused With Chlamydia?". 6 March 2019. https://www.mylabbox.com/chlamydia-trichomoniasis-confusion/. 
  9. ↑ 9.0 9.1 9.2 9.3 "Neglected parasitic infections in the United States: trichomoniasis". The American Journal of Tropical Medicine and Hygiene 90 (5): 800–804. May 2014. doi:10.4269/ajtmh.13-0723. PMID 24808247. 
  10. ↑ "Trichomoniasis and HIV interactions: a review". Sexually Transmitted Infections 89 (6): 426–33. September 2013. doi:10.1136/sextrans-2012-051005. PMID 23605851. 
  11. ↑ "Association of Trichomonas vaginalis and cytological abnormalities of the cervix in low risk women". PLOS ONE 8 (12): e86266. 30 December 2013. doi:10.1371/journal.pone.0086266. PMID 24386492. Bibcode: 2013PLoSO...886266D. 
  12. ↑ "Sexually transmitted infections and prostate cancer risk: a systematic review and meta-analysis". Cancer Epidemiology 38 (4): 329–38. August 2014. doi:10.1016/j.canep.2014.06.002. PMID 24986642. 
  13. ↑ "Prospective study of Trichomonas vaginalis infection and prostate cancer incidence and mortality: Physicians' Health Study". Journal of the National Cancer Institute 101 (20): 1406–11. October 2009. doi:10.1093/jnci/djp306. PMID 19741211. 
  14. ↑ "Trichomoniasis - CDC Fact Sheet". https://www.cdc.gov/std/trichomonas/STDFact-Trichomoniasis.htm. 
  15. ↑ "Trichomonas vaginalis kills and eats--evidence for phagocytic activity as a cytopathic effect". Parasitology 137 (1): 65–76. January 2010. doi:10.1017/S0031182009991041. PMID 19723359. 
  16. ↑ Scientists crack the genome of the parasite causing trichomoniasis . Physorg.com. Jan. 12, 2007.
  17. ↑ Epstein, Aaron; Roy, Subir (2010). "Chapter 50: Vulvovaginitis". Management of Common Problems in Obstetrics and Gynecology (5th ed.). Wiley-Blackwell. p. 228. ISBN 978-1405169165. https://books.google.com/books?id=6vMopyn84isC&q=trichomoniasis+microscope+common&pg=PA228. "In 80% of cases, the diagnosis of trichomoniasis is confirmed by microscopic examination of saline wet mount, with the observation of motile trichominondas; their shape is "football-like" with moving flagella." 
  18. ↑ "Trichomonas vaginalis: reevaluation of its clinical presentation and laboratory diagnosis". The Journal of Infectious Diseases 141 (2): 137–143. February 1980. doi:10.1093/infdis/141.2.137. PMID 6965976. 
  19. ↑ "Trichomoniasis". Clinical Microbiology Reviews 17 (4): 794–803, table of contents. October 2004. doi:10.1128/cmr.17.4.794-803.2004. PMID 15489349. 
  20. ↑ 20.0 20.1 "Comparison of APTIMA Trichomonas vaginalis transcription-mediated amplification to wet mount microscopy, culture, and polymerase chain reaction for diagnosis of trichomoniasis in men and women". American Journal of Obstetrics and Gynecology 200 (2): 188.e1–7. February 2009. doi:10.1016/j.ajog.2008.10.005. PMID 19185101. 
  21. ↑ 21.0 21.1 "Prevalence of Trichomonas vaginalis and coinfection with Chlamydia trachomatis and Neisseria gonorrhoeae in the United States as determined by the Aptima Trichomonas vaginalis nucleic acid amplification assay". Journal of Clinical Microbiology 50 (8): 2601–8. August 2012. doi:10.1128/JCM.00748-12. PMID 22622447. 
  22. ↑ Vaginitis/Trichomoniasis :Reduce your risk , American Social Health Association. Retrieved March 12, 2008.
  23. ↑ 23.0 23.1 Rob, Lukáš et al. (2008) (in cs). Gynekologie (2nd ed.). Prague: Galen. p. 136. ISBN 978-80-7262-501-7. 
  24. ↑ 24.0 24.1 24.2 24.3 "Point: new trichs for "old" dogs: prospects for expansion of Trichomonas vaginalis screening". Clinical Chemistry 60 (1): 151–4. January 2014. doi:10.1373/clinchem.2013.210021. PMID 24043491. 
  25. ↑ "Trichomoniasis: challenges to appropriate management". Clinical Infectious Diseases 44 (Suppl 3): S123-9. April 2007. doi:10.1086/511425. PMID 17342665. 
  26. ↑ 26.0 26.1 "Sexually transmitted diseases treatment guidelines, 2010". MMWR. Recommendations and Reports 59 (RR-12): 1–110. December 2010. PMID 21160459. 
  27. ↑ 27.0 27.1 "Implications of Trichomonas vaginalis nucleic acid amplification testing on medical training and practice". Journal of Clinical Microbiology 51 (5): 1650. May 2013. doi:10.1128/JCM.00188-13. PMID 23592856. 
  28. ↑ "Active recall to increase HIV and STI testing: a systematic review". Sexually Transmitted Infections 91 (5): 314–23. August 2015. doi:10.1136/sextrans-2014-051930. PMID 25759476: Access provided by the University of Pittsburgh Library System 
  29. ↑ "Failure of metronidazole to prevent preterm delivery among pregnant women with asymptomatic Trichomonas vaginalis infection". The New England Journal of Medicine 345 (7): 487–93. August 2001. doi:10.1056/NEJMoa003329. PMID 11519502. 
  30. ↑ McGregor, James A.; French, Janice I.; Parker, Ruth; Draper, Deborah; Patterson, Elisa; Jones, Ward; Thorsgard, Kyja; McFee, John (1995). "Prevention of premature birth by screening and treatment for common genital tract infections: Results of a prospective controlled evaluation". American Journal of Obstetrics and Gynecology 173 (1): 157–167. doi:10.1016/0002-9378(95)90184-1. PMID 7631673. 
  31. ↑ 31.0 31.1 31.2 "Sexually transmitted diseases treatment guidelines, 2015". MMWR. Recommendations and Reports 64 (RR-03): 1–137. June 2015. PMID 26042815. 
  32. ↑ Vaginitis/Trichomoniasis :Treatment for trichomoniasis , American Social Health Association. Retrieved March 12, 2008.
  33. ↑ 33.0 33.1 "Treatment of infections caused by metronidazole-resistant Trichomonas vaginalis". Clinical Microbiology Reviews 17 (4): 783–93, table of contents. October 2004. doi:10.1128/CMR.17.4.783-793.2004. PMID 15489348. 
  34. ↑ Cochrane Infectious Diseases Group, ed (2003-04-22). "Interventions for treating trichomoniasis in women". The Cochrane Database of Systematic Reviews (2): CD000218. doi:10.1002/14651858.CD000218. PMID 12804391. 
  35. ↑ "Incidence and predictors of reinfection with Trichomonas vaginalis in HIV-infected women". Sexually Transmitted Diseases 27 (5): 284–8. May 2000. doi:10.1097/00007435-200005000-00009. PMID 10821602. 
  36. ↑ "A randomized treatment trial: single versus 7-day dose of metronidazole for the treatment of Trichomonas vaginalis among HIV-infected women". Journal of Acquired Immune Deficiency Syndromes 55 (5): 565–71. December 2010. doi:10.1097/qai.0b013e3181eda955. PMID 21423852. 
  37. ↑ "Clinical and microbiological aspects of Trichomonas vaginalis". Clinical Microbiology Reviews 11 (2): 300–17. April 1998. doi:10.1128/CMR.11.2.300. PMID 9564565. 
  38. ↑ "Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013". Lancet 386 (9995): 743–800. August 2015. doi:10.1016/s0140-6736(15)60692-4. PMID 26063472. 
  39. ↑ "Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010". Lancet 380 (9859): 2163–96. December 2012. doi:10.1016/S0140-6736(12)61729-2. PMID 23245607. PMC 6350784. http://www.documentation.ird.fr/hor/fdi:010059240. 
  40. ↑ Centers for Disease Control and Prevention, National Center for HIV/AIDS, Viral Hepatitis, and TB. Division of STD Prevention. Trichomoniasis - CDC Fact Sheet. 2012.
  41. ↑ "Sexually transmitted infections among US women and men: prevalence and incidence estimates, 2008". Sexually Transmitted Diseases 40 (3): 187–93. March 2013. doi:10.1097/OLQ.0b013e318286bb53. PMID 23403598. 
  42. ↑ "The prevalence of Trichomonas vaginalis infection among reproductive-age women in the United States, 2001-2004". Clinical Infectious Diseases 45 (10): 1319–26. November 2007. doi:10.1086/522532. PMID 17968828. 
  43. ↑ "Epidemiology of undiagnosed trichomoniasis in a probability sample of urban young adults". PLOS ONE 9 (3): e90548. 2014. doi:10.1371/journal.pone.0090548. PMID 24626058. Bibcode: 2014PLoSO...990548R. 
  44. ↑ "Prevalence and factors associated with Trichomonas vaginalis infection among high-risk women in Los Angeles". Sexually Transmitted Diseases 40 (10): 804–7. October 2013. doi:10.1097/OLQ.0000000000000026. PMID 24275733. 

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