Chemistry:Secnidazole

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Short description: Chemical compound
Secnidazole
Secnidazole.svg
Clinical data
Trade namesSolosec
Other namesPM 185184, RP 14539
AHFS/Drugs.comInternational Drug Names
License data
Routes of
administration
Oral
ATC code
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
Chemical and physical data
FormulaC7H11N3O3
Molar mass185.183 g·mol−1
3D model (JSmol)
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Secnidazole (trade names Flagentyl, Sindose, Secnil, Solosec) is a nitroimidazole anti-infective. Effectiveness in the treatment of dientamoebiasis has been reported.[1] It has also been tested against Atopobium vaginae.[2]

In the United States, secnidazole is FDA approved for the treatment of bacterial vaginosis and trichomoniasis in adult women.[3]

References

  1. "Dientamoeba fragilis, a neglected cause of diarrhea, successfully treated with secnidazole". Clinical Microbiology and Infection 9 (2): 110–3. February 2003. doi:10.1046/j.1469-0691.2003.00504.x. PMID 12588330. 
  2. "In vitro activity of secnidazole against Atopobium vaginae, an anaerobic pathogen involved in bacterial vaginosis". Clinical Microbiology and Infection 16 (5): 470–2. May 2010. doi:10.1111/j.1469-0691.2009.02852.x. PMID 19548924. 
  3. "Secnidazole for Trichomoniasis in Women and Men". Sex Med Rev 10 (2): 255–262. April 2022. doi:10.1016/j.sxmr.2021.12.004. PMID 35153156. 

Further reading

  • "Secnidazole. A review of its antimicrobial activity, pharmacokinetic properties and therapeutic use in the management of protozoal infections and bacterial vaginosis". Drugs 51 (4): 621–38. April 1996. doi:10.2165/00003495-199651040-00007. PMID 8706597.