Chemistry:Tinidazole
Tinidazole, sold under the brand name Tindamax among others, is a medication used against protozoan infections. It is widely known throughout Europe and the developing world as a treatment for a variety of anaerobic amoebic and bacterial infections. It was developed in 1972 and is a prominent member of the nitroimidazole antibiotic class.[1]
Tinidazole is a therapeutic alternative on the World Health Organization's List of Essential Medicines.[2]
Medical uses
Tinidazole may be a therapeutic alternative in the setting of metronidazole intolerance. Tinidazole is used to treat Helicobacter pylori, Amoebic dysentery, Giardia and Trichomonas vaginalis.[3]
Side effects
Drinking alcohol while taking tinidazole causes an unpleasant disulfiram-like reaction, which includes nausea, vomiting, headache, increased blood pressure, flushing, and shortness of breath.
Pharmacology
Pharmacokinetics
Elimination half-life is 13.2 ± 1.4 hours. Plasma half-life is 12 to 14 hours.
History
Tinidazole was approved for medical treatment in the United States in 2004.[4][5]
See also
- Fenticonazole nitrate/lidocaine/tinidazole
References
- ↑ "Imidazole and Derivatives.". In Ullmann's Encyclopedia of Industrial Chemistry. Wiley-VCH. 2002. doi:10.1002/14356007.a13_661. ISBN 3527306730.
- ↑ The selection and use of essential medicines, 2025: WHO Model List of Essential Medicines, 24th list. Geneva: World Health Organization. 2025.
- ↑ "Nitroimidazole drugs--action and resistance mechanisms. I. Mechanisms of action". The Journal of Antimicrobial Chemotherapy 31 (1): 9–20. January 1993. doi:10.1093/jac/31.1.9. PMID 8444678.
- ↑ Cite error: Invalid
<ref>tag; no text was provided for refs namedTindamax FDA label - ↑ "Drug Approval Package: Tindamax (Tinidazole) NDA #021618, 021681 & 021682". https://www.accessdata.fda.gov/drugsatfda_docs/nda/2004/21-618_21-681_21-682_Tindamax.cfm.
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