Biology:Dolichyl-phosphate alpha-N-acetylglucosaminyltransferase
| dolichyl-phosphate alpha-N-acetylglucosaminyltransferase | |||||||||
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| Identifiers | |||||||||
| EC number | 2.4.1.153 | ||||||||
| CAS number | 63363-73-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a dolichyl-phosphate alpha-N-acetylglucosaminyltransferase (EC 2.4.1.153) is an enzyme that catalyzes the chemical reaction
- UDP-N-acetyl-D-glucosamine + dolichyl phosphate [math]\displaystyle{ \rightleftharpoons }[/math] UDP + dolichyl N-acetyl-alpha-D-glucosaminyl phosphate
Thus, the two substrates of this enzyme are UDP-N-acetyl-D-glucosamine and dolichyl phosphate, whereas its two products are UDP and dolichyl N-acetyl-alpha-D-glucosaminyl phosphate.
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-N-acetyl-D-glucosamine:dolichyl-phosphate alpha-N-acetyl-D-glucosaminyltransferase. Other names in common use include uridine diphosphoacetylglucosamine-dolichol phosphate, acetylglucosaminyltransferase, dolichyl phosphate acetylglucosaminyltransferase, dolichyl phosphate N-acetylglucosaminyltransferase, UDP-N-acetylglucosamine-dolichol phosphate, and N-acetylglucosaminyltransferase.
References
- "The biosynthesis of a N,N'-diacetylchitobiose containing lipid by liver microsomes. A probable dolichol pyrophosphate derivative". Biochem. Biophys. Res. Commun. 52 (4): 1285–92. 1973. doi:10.1016/0006-291X(73)90640-2. PMID 4717748.
- "Phosphoryl-N-acetylglucosamine transfer to a lipid acceptor of liver microsomal preparations". Biochim. Biophys. Acta 239 (3): 401–10. 1971. doi:10.1016/0005-2760(71)90033-6. PMID 5113503.
- "Incorporation of carbohydrates into endogenous acceptors of liver microsomal fractions". Arch. Biochem. Biophys. 138 (1): 135–46. 1970. doi:10.1016/0003-9861(70)90292-4. PMID 4315690.
- "Chemical synthesis of P1-2-acetamido-2-deoxy-alpha-D-glucopyranosyl P2-dolichyl pyrophosphate". Carbohydr. Res. 37 (1): 252–60. 1974. doi:10.1016/S0008-6215(00)87080-9. PMID 4371972.
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