Biology:Fibrolase
From HandWiki
Fibrolase (EC 3.4.24.72, fibrinolytic proteinase, Agkistrodon contortrix contortrix metalloproteinase, Agkistrodon contortrix contortrix venom metalloproteinase) is an enzyme.[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- Hydrolysis of -Ala14-Leu- in insulin B chain and -Lys413-Leu- in alpha-chain of fibrinogen
This enzyme is present in the venom of the southern copperhead snake (Agkistrodon contortrix contortrix).
References
- ↑ "A direct-acting fibrinolytic enzyme from the venom of Agkistrodon contortrix contortrix: effects on various components of the human blood coagulation and fibrinolysis systems". Thrombosis Research 52 (6): 541–52. December 1988. doi:10.1016/0049-3848(88)90127-2. PMID 3232124.
- ↑ "Purification and characterization of a fibrinolytic enzyme from venom of the southern copperhead snake (Agkistrodon contortrix contortrix)". Archives of Biochemistry and Biophysics 289 (2): 197–207. September 1991. doi:10.1016/0003-9861(91)90462-r. PMID 1898066.
- ↑ "Amino acid sequence of fibrolase, a direct-acting fibrinolytic enzyme from Agkistrodon contortrix contortrix venom". Protein Science 1 (5): 590–600. May 1992. doi:10.1002/pro.5560010505. PMID 1304358.
- ↑ "Resolution of isoforms of natural and recombinant fibrolase, the fibrinolytic enzyme from Agkistrodon contortrix contortrix snake venom, and comparison of their EDTA sensitivities". Journal of Chromatography B 662 (2): 227–43. December 1994. doi:10.1016/0378-4347(94)00202-9. PMID 7719479.
- ↑ "Fibrinolytic enzymes from the venoms of Agkistrodon contortrix contortrix and Crotalus basiliscus basiliscus: cleavage site specificity towards the alpha-chain of fibrin". Thrombosis Research 74 (4): 355–67. May 1994. doi:10.1016/0049-3848(94)90151-1. PMID 8085237.
External links
- Fibrolase at the US National Library of Medicine Medical Subject Headings (MeSH)
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