Biology:N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase

From HandWiki
Revision as of 09:12, 10 February 2024 by Smart bot editor (talk | contribs) (simplify)
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Short description: Class of enzymes
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase
Identifiers
EC number2.4.1.149
CAS number85638-39-7
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase (EC 2.4.1.149) is an enzyme that catalyzes the chemical reaction

UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R [math]\displaystyle{ \rightleftharpoons }[/math] UDP + N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-D- glucosaminyl-R

Thus, the two substrates of this enzyme are UDP-N-acetyl-D-glucosamine and beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R, whereas its 3 products are UDP, N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-D-, and glucosaminyl-R.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-D-glucosam ine beta-1,3-acetyl-D-glucosaminyltransferase. Other names in common use include uridine diphosphoacetylglucosamine-acetyllactosaminide, beta1->3-acetylglucosaminyltransferase, poly-N-acetyllactosamine extension enzyme, Galbeta1->4GlcNAc-R beta1->3 N-acetylglucosaminyltransferase, UDP-GlcNAc:GalR, beta-D-3-N-acetylglucosaminyltransferase, N-acetyllactosamine beta(1-3)N-acetylglucosaminyltransferase, UDP-GlcNAc:Galbeta1->4GlcNAcbeta-Rbeta1->3-N-, acetylglucosaminyltransferase, and GnTE. This enzyme participates in 4 metabolic pathways: keratan sulfate biosynthesis, glycosphingolipid biosynthesis - neo-lactoseries, glycan structures - biosynthesis 1, and glycan structures - biosynthesis 2.

References

  • "The presence of N-acetyllactosamine and lactose: beta (1-3)N-acetylglucosaminyltransferase activity in human urine". Jpn. J. Med. Sci. Biol. 38 (1): 1–8. 1985. doi:10.7883/yoken1952.38.1. PMID 3160874. 
  • "Novikoff ascites tumor cells contain N-acetyllactosaminide beta 1 leads to 3 and beta 1 leads to 6 N-acetylglucosaminyltransferase activity". J. Biol. Chem. 258 (6): 3435–7. 1983. PMID 6219989.