Biology:Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase
| alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase | |||||||||
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| Identifiers | |||||||||
| EC number | 2.4.99.3 | ||||||||
| CAS number | 71124-50-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, an alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase (EC 2.4.99.3) is an enzyme that catalyzes the chemical reaction
- CMP-N-acetylneuraminate + glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein [math]\displaystyle{ \rightleftharpoons }[/math] CMP + glycano-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)- glycoprotein
Thus, the two substrates of this enzyme are CMP-N-acetylneuraminate and glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein, whereas its 3 products are CMP, glycano-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-, and glycoprotein.
This enzyme belongs to the family of transferases, specifically those glycosyltransferases that do not transfer hexosyl or pentosyl groups. The systematic name of this enzyme class is CMP-N-acetylneuraminate:glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein alpha-2,6-N-acetylneuraminyltransferase. This enzyme participates in o-glycan biosynthesis and glycan structures - biosynthesis 1.
References
- "Purification to homogeneity and enzymatic characterization of an alpha-N-acetylgalactosaminide alpha 2 leads to 6 sialyltransferase from porcine submaxillary glands". J. Biol. Chem. 254 (13): 5934–41. 1979. PMID 447688.
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