Biology:FUT6
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Alpha-(1,3)-fucosyltransferase is an enzyme that in humans is encoded by the FUT6 gene.[1][2][3]
The alpha-1,3-fucosyltransferases constitute a large family of glycosyltransferases with a high degree of homology. The enzymes of this family comprise 3 main activity patterns called myeloid, plasma, and Lewis, based on their capacity to transfer alpha-L-fucose to distinct oligosaccharide acceptors, their sensitivity to N-ethylmaleimide inhibition, their cation requirements, and their tissue-specific expression patterns. The different categories of alpha-1,3-fucosyltransferases are sequentially expressed during embryo-fetal development.[supplied by OMIM][3]
References
- ↑ "The cloning and expression of a human alpha-1,3 fucosyltransferase capable of forming the E-selectin ligand". Biochem Biophys Res Commun 187 (1): 152–7. Oct 1992. doi:10.1016/S0006-291X(05)81472-X. PMID 1520296.
- ↑ "Physical maps of human alpha (1,3)fucosyltransferase genes FUT3-FUT6 on chromosomes 19p13.3 and 11q21". Genomics 26 (1): 142–6. Jul 1995. doi:10.1016/0888-7543(95)80094-3. PMID 7782074.
- ↑ 3.0 3.1 "Entrez Gene: FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2528.
Further reading
- "Molecular cloning of a fourth member of a human alpha (1,3)fucosyltransferase gene family. Multiple homologous sequences that determine expression of the Lewis x, sialyl Lewis x, and difucosyl sialyl Lewis x epitopes.". J. Biol. Chem. 267 (34): 24575–84. 1992. doi:10.1016/S0021-9258(18)35803-4. PMID 1339443.
- "Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms.". J. Biol. Chem. 270 (34): 20112–22. 1995. doi:10.1074/jbc.270.34.20112. PMID 7650030.
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "Molecular basis for plasma alpha(1,3)-fucosyltransferase gene deficiency (FUT6).". J. Biol. Chem. 269 (17): 12662–71. 1994. doi:10.1016/S0021-9258(18)99927-8. PMID 8175676.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "alpha1,3Fucosyltransferase VI is expressed in HepG2 cells and codistributed with beta1,4galactosyltransferase I in the golgi apparatus and monensin-induced swollen vesicles.". Glycobiology 9 (11): 1273–80. 2000. doi:10.1093/glycob/9.11.1273. PMID 10536043.
- "Localization of alpha 1,3-fucosyltransferase VI in Weibel-Palade bodies of human endothelial cells.". Proc. Natl. Acad. Sci. U.S.A. 97 (15): 8369–74. 2000. doi:10.1073/pnas.97.15.8369. PMID 10900002. Bibcode: 2000PNAS...97.8369S.
- "Neutrophils promote the release of alpha-6-fucosyltransferase from blood platelets through the action of cathepsin G and elastase.". Biochimie 83 (8): 739–42. 2001. doi:10.1016/S0300-9084(01)01306-2. PMID 11530205.
- "Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism.". J. Biol. Chem. 277 (5): 3168–75. 2002. doi:10.1074/jbc.M107927200. PMID 11698403.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Expression levels of FUT6 gene transfected into human colon carcinoma cells switch two sialyl-Lewis X-related carbohydrate antigens with distinct properties in cell adhesion.". Biochem. Biophys. Res. Commun. 303 (3): 896–901. 2003. doi:10.1016/S0006-291X(03)00420-0. PMID 12670495.
- "Activity and tissue distribution of splice variants of alpha6-fucosyltransferase in human embryogenesis.". Glycobiology 14 (1): 13–25. 2004. doi:10.1093/glycob/cwh006. PMID 14514715.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. 2006. doi:10.1101/gr.4039406. PMID 16344560.
- "Interleukin-1beta induces sialyl Lewis X on hepatocellular carcinoma HuH-7 cells via enhanced expression of ST3Gal IV and FUT VI gene.". FEBS Lett. 580 (26): 6069–75. 2007. doi:10.1016/j.febslet.2006.09.073. PMID 17054948.
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