Biology:Alcohol dehydrogenase (nicotinoprotein)
From HandWiki
| Alcohol dehydrogenase (nicotinoprotein) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.1.99.36 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Alcohol dehydrogenase (nicotinoprotein) (EC 1.1.99.36, NDMA-dependent alcohol dehydrogenase, nicotinoprotein alcohol dehydrogenase, np-ADH, ethanol:N,N-dimethyl-4-nitrosoaniline oxidoreductase) is an enzyme with systematic name ethanol:acceptor oxidoreductase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- ethanol + acceptor [math]\displaystyle{ \rightleftharpoons }[/math] acetaldehyde + reduced acceptor
This enzyme contains Zn2+.
References
- ↑ "Nicotinoprotein [NAD(P)-containing] alcohol/aldehyde oxidoreductases. Purification and characterization of a novel type from Amycolatopsis methanolica". European Journal of Biochemistry 212 (3): 819–26. March 1993. doi:10.1111/j.1432-1033.1993.tb17723.x. PMID 8385013.
- ↑ "Optical spectroscopy of nicotinoprotein alcohol dehydrogenase from Amycolatopsis methanolica: a comparison with horse liver alcohol dehydrogenase and UDP-galactose epimerase". Biochemistry 37 (9): 3068–77. March 1998. doi:10.1021/bi972115u. PMID 9485460.
- ↑ "Nicotinoprotein (NADH-containing) alcohol dehydrogenase from Rhodococcus erythropolis DSM 1069: an efficient catalyst for coenzyme-independent oxidation of a broad spectrum of alcohols and the interconversion of alcohols and aldehydes". Microbiology 146 ( Pt 4) (4): 775–85. April 2000. doi:10.1099/00221287-146-4-775. PMID 10784035.
- ↑ "Inhibition of nicotinoprotein (NAD+-containing) alcohol dehydrogenase by trans-4-(N,N-dimethylamino)-cinnamaldehyde binding to the active site". Journal of Protein Chemistry 22 (5): 457–61. July 2003. doi:10.1023/b:jopc.0000005461.53788.ee. PMID 14690248.
- ↑ "Nicotinoprotein (NAD+ -containing) alcohol dehydrogenase: structural relationships and functional interpretations". Cellular and Molecular Life Sciences 60 (5): 999–1006. May 2003. doi:10.1007/s00018-003-3105-9. PMID 12827287.
External links
- Alcohol+dehydrogenase+(nicotinoprotein) at the US National Library of Medicine Medical Subject Headings (MeSH)
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