Biology:Testosterone 17beta-dehydrogenase

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testosterone 17-beta-dehydrogenase (NAD+)
Identifiers
EC number1.1.1.63
CAS number9028-62-0
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
testosterone 17-beta-dehydrogenase (NADP+)
Identifiers
EC number1.1.1.64
CAS number9028-63-1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a testosterone 17beta-dehydrogenase is an enzyme that catalyzes the chemical reaction between testosterone and androst-4-ene-3,17-dione. This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor.

The systematic name of this enzyme class is 17beta-hydroxysteroid:NAD+ 17-oxidoreductase. Other names in common use include 17-ketoreductase and 17beta-HSD. This enzyme participates in androgen and estrogen metabolism.

Variants

There are two variants of the enzyme, one that uses NAD+ as a substrate, and one that uses NADP+ as acceptor.

NAD+

Main page: Biology:3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)

This variant of testosterone 17beta-dehydrogenase (EC 1.1.1.239) catalyzes the reaction

testosterone + NAD+ [math]\displaystyle{ \rightleftharpoons }[/math] androst-4-ene-3,17-dione + NADH + H+

Thus, the two substrates of this enzyme are testosterone and NAD+, whereas its 3 products are androst-4-ene-3,17-dione, NADH, and H+.

NADP+

Main page: Biology:Testosterone 17b-dehydrogenase (NADP+)

This variant of testosterone 17beta-dehydrogenase (EC 1.1.1.64) catalyzes the reaction

testosterone + NADP+ [math]\displaystyle{ \rightleftharpoons }[/math] androst-4-ene-3,17-dione + NADPH + H+

Thus, the two substrates of this enzyme are testosterone and NADP+, whereas its 3 products are androst-4-ene-3,17-dione, NADPH, and H+.

References

  • "Separation of a Triphosphopyridine Nucleotide-specific from a Diphosphopyridine Nucleotide-specific 17β-Hydroxy-(testosterone)dehydrogenase of Guinea Pig Liver". J. Biol. Chem. 235 (10): 2792–6. 1960. doi:10.1016/S0021-9258(18)64542-9. PMID 13696735. 
  • "Preparation and characterization of the enzyme which converts testosterone to androstenedione". J. Biol. Chem. 185 (1): 75–84. 1950. doi:10.1016/S0021-9258(18)56395-X. PMID 15436478. 
  • Villee CA; Spencer JM (1960). "Some Properties of the Pyridine Nucleotide-specific 17β-Hydroxy Steroid Dehydrogenases of Guinea Pig Liver". J. Biol. Chem. 235 (12): 3615–3619. doi:10.1016/S0021-9258(18)64518-1. PMID 13781425. 

External links