Biology:Testosterone 17beta-dehydrogenase
testosterone 17-beta-dehydrogenase (NAD+) | |||||||||
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Identifiers | |||||||||
EC number | 1.1.1.63 | ||||||||
CAS number | 9028-62-0 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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testosterone 17-beta-dehydrogenase (NADP+) | |||||||||
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Identifiers | |||||||||
EC number | 1.1.1.64 | ||||||||
CAS number | 9028-63-1 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a testosterone 17beta-dehydrogenase is an enzyme that catalyzes the chemical reaction between testosterone and androst-4-ene-3,17-dione. This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor.
The systematic name of this enzyme class is 17beta-hydroxysteroid:NAD+ 17-oxidoreductase. Other names in common use include 17-ketoreductase and 17beta-HSD. This enzyme participates in androgen and estrogen metabolism.
Variants
There are two variants of the enzyme, one that uses NAD+ as a substrate, and one that uses NADP+ as acceptor.
NAD+
This variant of testosterone 17beta-dehydrogenase (EC 1.1.1.239) catalyzes the reaction
- testosterone + NAD+ [math]\displaystyle{ \rightleftharpoons }[/math] androst-4-ene-3,17-dione + NADH + H+
Thus, the two substrates of this enzyme are testosterone and NAD+, whereas its 3 products are androst-4-ene-3,17-dione, NADH, and H+.
NADP+
This variant of testosterone 17beta-dehydrogenase (EC 1.1.1.64) catalyzes the reaction
- testosterone + NADP+ [math]\displaystyle{ \rightleftharpoons }[/math] androst-4-ene-3,17-dione + NADPH + H+
Thus, the two substrates of this enzyme are testosterone and NADP+, whereas its 3 products are androst-4-ene-3,17-dione, NADPH, and H+.
References
- "Separation of a Triphosphopyridine Nucleotide-specific from a Diphosphopyridine Nucleotide-specific 17β-Hydroxy-(testosterone)dehydrogenase of Guinea Pig Liver". J. Biol. Chem. 235 (10): 2792–6. 1960. doi:10.1016/S0021-9258(18)64542-9. PMID 13696735.
- "Preparation and characterization of the enzyme which converts testosterone to androstenedione". J. Biol. Chem. 185 (1): 75–84. 1950. doi:10.1016/S0021-9258(18)56395-X. PMID 15436478.
- Villee CA; Spencer JM (1960). "Some Properties of the Pyridine Nucleotide-specific 17β-Hydroxy Steroid Dehydrogenases of Guinea Pig Liver". J. Biol. Chem. 235 (12): 3615–3619. doi:10.1016/S0021-9258(18)64518-1. PMID 13781425.
External links
Original source: https://en.wikipedia.org/wiki/Testosterone 17beta-dehydrogenase.
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