Biology:ADAMDEC1

Short description: Protein

ADAM-like, decysin 1 is a protein that in humans is encoded by the ADAMDEC1 gene.

Function

This encoded protein is thought to be a secreted protein belonging to the disintegrin metalloproteinase family. Its expression is upregulated during the maturation of dendritic cells. This protein may play an important role in dendritic cell function and their interactions with germinal center T cells. [provided by RefSeq, Jul 2008].

Further reading

• Mueller, C. G.; Rissoan, M. C.; Salinas, B; Ait-Yahia, S; Ravel, O; Bridon, J. M.; Briere, F; Lebecque, S et al. (1997). "Polymerase chain reaction selects a novel disintegrin proteinase from CD40-activated germinal center dendritic cells". The Journal of Experimental Medicine 186 (5): 655–63. doi:10.1084/jem.186.5.655. PMID 9271581. 
• Bates, E. E.; Fridman, W. H.; Mueller, C. G. (2002). "The ADAMDEC1 (decysin) gene structure: Evolution by duplication in a metalloprotease gene cluster on chromosome 8p12". Immunogenetics 54 (2): 96–105. doi:10.1007/s00251-002-0430-3. PMID 12037602. 
• Fritsche, J; Müller, A; Hausmann, M; Rogler, G; Andreesen, R; Kreutz, M (2003). "Inverse regulation of the ADAM-family members, decysin and MADDAM/ADAM19 during monocyte differentiation". Immunology 110 (4): 450–7. doi:10.1111/j.1365-2567.2003.01754.x. PMID 14632642. 
• Crouser, E. D.; Culver, D. A.; Knox, K. S.; Julian, M. W.; Shao, G; Abraham, S; Liyanarachchi, S; Macre, J. E. et al. (2009). "Gene expression profiling identifies MMP-12 and ADAMDEC1 as potential pathogenic mediators of pulmonary sarcoidosis". American Journal of Respiratory and Critical Care Medicine 179 (10): 929–38. doi:10.1164/rccm.200803-490OC. PMID 19218196. 
• Mueller, C. G.; Cremer, I; Paulet, P. E.; Niida, S; Maeda, N; Lebeque, S; Fridman, W. H.; Sautès-Fridman, C (2001). "Mannose receptor ligand-positive cells express the metalloprotease decysin in the B cell follicle". Journal of Immunology 167 (9): 5052–60. doi:10.4049/jimmunol.167.9.5052. PMID 11673514. 
• Berger, M; Moscatelli, H; Kulle, B; Luxembourg, B; Blouin, K; Spannagl, M; Lindhoff-Last, E; Schambeck, C. M. (2008). "Association of ADAMDEC1 haplotype with high factor VIII levels in venous thromboembolism". Thrombosis and Haemostasis 99 (5): 905–8. doi:10.1160/TH08-01-0059. PMID 18449420. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.