Biology:ADAM2
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Disintegrin and metalloproteinase domain-containing protein 2 or Beta-fertilin[1] is an enzyme that in humans is encoded by the ADAM2 gene.[2][3][4]
Function
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell–cell and cell–matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a subunit of an integral sperm membrane heterodimer glycoprotein called fertilin, which plays an important role in sperm-egg interactions.[4] The other subunit is ADAM1 or alpha-fertilin.[1]
References
- ↑ 1.0 1.1 "Expression, immunolocalization and processing of fertilins ADAM-1 and ADAM-2 in the boar (Sus domesticus) spermatozoa during epididymal maturation". Reproductive Biology and Endocrinology 9: 96. June 2011. doi:10.1186/1477-7827-9-96. PMID 21718510.
- ↑ "Molecular cloning of the human fertilin beta subunit". Biochemical and Biophysical Research Communications 224 (2): 318–26. July 1996. doi:10.1006/bbrc.1996.1027. PMID 8702389.
- ↑ "Mapping, sequence, and expression analysis of the human fertilin beta gene (FTNB)". Genomics 40 (1): 190–2. February 1997. doi:10.1006/geno.1996.4531. PMID 9070941.
- ↑ 4.0 4.1 "Entrez Gene: ADAM2 ADAM metallopeptidase domain 2 (fertilin beta)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2515.
Further reading
- "Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications for sperm-egg binding and other cell interactions". The Journal of Biological Chemistry 277 (20): 17804–10. May 2002. doi:10.1074/jbc.M200086200. PMID 11882657.
- "Calmegin is required for fertilin alpha/beta heterodimerization and sperm fertility". Developmental Biology 240 (1): 254–61. December 2001. doi:10.1006/dbio.2001.0462. PMID 11784061.
- "Analysis of mouse fertilin in wild-type and fertilin beta(-/-) sperm: evidence for C-terminal modification, alpha/beta dimerization, and lack of essential role of fertilin alpha in sperm-egg fusion". Developmental Biology 222 (2): 289–95. June 2000. doi:10.1006/dbio.2000.9703. PMID 10837118.
- "Role of the integrin-associated protein CD9 in binding between sperm ADAM 2 and the egg integrin alpha6beta1: implications for murine fertilization". Proceedings of the National Academy of Sciences of the United States of America 96 (21): 11830–5. October 1999. doi:10.1073/pnas.96.21.11830. PMID 10518536. Bibcode: 1999PNAS...9611830C.
- "Mediation of sperm-egg fusion: evidence that mouse egg alpha6beta1 integrin is the receptor for sperm fertilinbeta". Chemistry & Biology 6 (1): 1–10. January 1999. doi:10.1016/S1074-5521(99)80015-5. PMID 9889149.
- "Human fertilin beta: identification, characterization, and chromosomal mapping of an ADAM gene family member". Molecular Reproduction and Development 46 (3): 363–9. March 1997. doi:10.1002/(SICI)1098-2795(199703)46:3<363::AID-MRD15>3.0.CO;2-#. PMID 9041139.
- "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". The Journal of Infection 24 (3): 317–20. May 1992. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
External links
- The MEROPS online database for peptidases and their inhibitors: M12.950
- Human ADAM2 genome location and ADAM2 gene details page in the UCSC Genome Browser.
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