Biology:Methanol dehydrogenase (nicotinoprotein)

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Methanol dehydrogenase (nicotinoprotein)
Identifiers
EC number1.1.99.37
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Methanol dehydrogenase (nicotinoprotein) (EC 1.1.99.37, NDMA-dependent methanol dehydrogenase, nicotinoprotein methanol dehydrogenase, methanol:N,N-dimethyl-4-nitrosoaniline oxidoreductase) is an enzyme with systematic name methanol:acceptor oxidoreductase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction

methanol + acceptor [math]\displaystyle{ \rightleftharpoons }[/math] formaldehyde + reduced acceptor

This enzyme contains Zn2+ and Mg2+.

References

  1. "Electron microscopic analysis and biochemical characterization of a novel methanol dehydrogenase from the thermotolerant Bacillus sp. C1". The Journal of Biological Chemistry 266 (6): 3949–54. February 1991. PMID 1995642. 
  2. "Nicotinoprotein [NAD(P)-containing] alcohol/aldehyde oxidoreductases. Purification and characterization of a novel type from Amycolatopsis methanolica". European Journal of Biochemistry 212 (3): 819–26. March 1993. doi:10.1111/j.1432-1033.1993.tb17723.x. PMID 8385013. 
  3. "Electron microscopic analysis and structural characterization of novel NADP(H)-containing methanol: N,N'-dimethyl-4-nitrosoaniline oxidoreductases from the gram-positive methylotrophic bacteria Amycolatopsis methanolica and Mycobacterium gastri MB19". Journal of Bacteriology 175 (6): 1814–22. March 1993. doi:10.1128/jb.175.6.1814-1822.1993. PMID 8449887. 
  4. "Identification of a magnesium-dependent NAD(P)(H)-binding domain in the nicotinoprotein methanol dehydrogenase from Bacillus methanolicus". The Journal of Biological Chemistry 277 (49): 46966–73. December 2002. doi:10.1074/jbc.M207547200. PMID 12351635. 
  5. "Identification and functional characterization of a gene for the methanol : N,N'-dimethyl-4-nitrosoaniline oxidoreductase from Mycobacterium sp. strain JC1 (DSM 3803)". Microbiology 156 (Pt 2): 463–71. February 2010. doi:10.1099/mic.0.034124-0. PMID 19875438. 

External links