Biology:Galactosyldiacylglycerol alpha-2,3-sialyltransferase

From HandWiki
Revision as of 07:44, 12 February 2024 by DanMescoff (talk | contribs) (over-write)
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Short description: Class of enzymes
galactosyldiacylglycerol alpha-2,3-sialyltransferase
Identifiers
EC number2.4.99.5
CAS number80237-98-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a galactosyldiacylglycerol alpha-2,3-sialyltransferase (EC 2.4.99.5) is an enzyme that catalyzes the chemical reaction

CMP-N-acetylneuraminate + 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol [math]\displaystyle{ \rightleftharpoons }[/math] CMP + 1,2-diacyl-3-[3-(alpha-D-N-acetylneuraminyl)-beta-D-galactosyl]-sn- glycerol

Thus, the two substrates of this enzyme are CMP-N-acetylneuraminate and 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol, whereas its 3 products are CMP, 1,2-diacyl-3-[3-(alpha-D-N-acetylneuraminyl)-beta-D-galactosyl]-sn-, and glycerol.

This enzyme belongs to the family of transferases, specifically those glycosyltransferases that do not transfer hexosyl or pentosyl groups. The systematic name of this enzyme class is CMP-N-acetylneuraminate:1,2-diacyl-3-beta-D-galactosyl-sn-glycerol N-acetylneuraminyltransferase. This enzyme participates in glycerolipid metabolism.

References

  • "Biosynthesis in vitro of sialosylgalactosyldiacylglycerol by mouse brain microsomes". J. Biol. Chem. 256 (23): 12306–9. 1981. PMID 7298658. 
  • "Purification of a Gal beta 1 to 4GlcNAc alpha 2 to 6 sialyltransferase and a Gal beta 1 to 3(4)GlcNAc alpha 2 to 3 sialyltransferase to homogeneity from rat liver". J. Biol. Chem. 257 (22): 13835–44. 1982. PMID 7142179. 
  • "Sialylation of glycoprotein oligosaccharides N-linked to asparagine Enzymatic characterization of a Gal beta 1 to 3(4)GlcNAc alpha 2 to 3 sialyltransferase and a Gal beta 1 to 4GlcNAc alpha 2 to 6 sialyltransferase from rat liver". J. Biol. Chem. 257 (22): 13845–53. 1982. PMID 7142180.