Biology:Glucosylceramide beta-1,4-galactosyltransferase
From HandWiki
Short description: Class of enzymes
| Glucosylceramide beta-1,4-galactosyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.4.1.274 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Glucosylceramide beta-1,4-galactosyltransferase (EC 2.4.1.274, lactosylceramide synthase, uridine diphosphate-galactose:glucosyl ceramide beta 1-4 galactosyltransferase, UDP-Gal:glucosylceramide beta1->4galactosyltransferase, GalT-2, UDP-galactose:beta-D-glucosyl-(1<->1)-ceramide beta-1,4-galactosyltransferase) is an enzyme with systematic name UDP-alpha-D-galactose:beta-D-glucosyl-(1<->1)-ceramide 4-beta-D-galactosyltransferase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- UDP-alpha-D-galactose + beta-D-glucosyl-(1<->1)-ceramide [math]\displaystyle{ \rightleftharpoons }[/math] UDP + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
Involved in the synthesis of several different major classes of glycosphingolipids.
References
- ↑ "UDPgalactose:glucosylceramide beta 1----4-galactosyltransferase activity in human proximal tubular cells from normal and familial hypercholesterolemic homozygotes". Biochimica et Biophysica Acta 923 (1): 136–42. January 1987. doi:10.1016/0304-4165(87)90136-X. PMID 3099851.
- ↑ "Localization in the Golgi apparatus of rat liver UDP-Gal:glucosylceramide beta 1----4galactosyltransferase". Biochemistry 30 (10): 2719–24. March 1991. doi:10.1021/bi00224a021. PMID 1900430.
- ↑ "Purification of uridine diphosphate-galactose:glucosyl ceramide, beta 1-4 galactosyltransferase from human kidney". The Journal of Biological Chemistry 267 (10): 7148–53. April 1992. doi:10.1016/S0021-9258(19)50550-6. PMID 1551920.
- ↑ "Purification, cDNA cloning, and expression of UDP-Gal: glucosylceramide beta-1,4-galactosyltransferase from rat brain". The Journal of Biological Chemistry 273 (22): 13570–7. May 1998. doi:10.1074/jbc.273.22.13570. PMID 9593693.
- ↑ "cDNA cloning and expression of human lactosylceramide synthase". Biochimica et Biophysica Acta 1438 (2): 301–4. May 1999. doi:10.1016/S1388-1981(99)00051-7. PMID 10320813.
External links
- Glucosylceramide+beta-1,4-galactosyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)
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