Biology:KLK1

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Kallikrein-1 is a protein that in humans is encoded by the KLK1 gene. KLK1 is a member of the peptidase S1 family.

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen.

See also

• Kinin–kallikrein system
• Kininogen 1

Further reading

• "The expanded human kallikrein (KLK) gene family: genomic organisation, tissue-specific expression and potential functions.". Biol. Chem. 382 (1): 5–14. 2001. doi:10.1515/BC.2001.002. PMID 11258672. http://espace.library.uq.edu.au/view/UQ:364944/UQ364944_OA.pdf. 
• "N-Terminal amino acid sequence of human urinary kallikrein homology with other serine proteases.". Hoppe-Seyler's Z. Physiol. Chem. 360 (12): 1947–50. 1980. PMID 393608. 
• "Characterization of the human kallikrein locus.". Genomics 14 (1): 6–11. 1992. doi:10.1016/S0888-7543(05)80275-7. PMID 1385301. 
• "Expression of the gene coding for human prostate-specific antigen and related hGK-1 in benign and malignant tumors of the human prostate.". Int. J. Cancer 45 (4): 654–60. 1990. doi:10.1002/ijc.2910450414. PMID 1691151. 
• "Localization of human glandular kallikrein-1 gene to chromosome 19q13.3-13.4 by in situ hybridization.". Hum. Hered. 41 (4): 222–6. 1992. doi:10.1159/000154005. PMID 1783409. 
• "Human urinary kallikrein. Complete amino acid sequence and sites of glycosylation.". Int. J. Pept. Protein Res. 33 (4): 237–49. 1989. doi:10.1111/j.1399-3011.1989.tb01277.x. PMID 2666327. 
• "Cloning and expression of human salivary-gland kallikrein in Escherichia coli.". Biochem. J. 262 (3): 787–93. 1990. doi:10.1042/bj2620787. PMID 2686621. 
• "Structure and chromosomal localization of the human renal kallikrein gene.". Biochemistry 27 (9): 3124–9. 1988. doi:10.1021/bi00409a003. PMID 2898948. 
• "Nucleotide sequence of cloned cDNA for human pancreatic kallikrein.". Biochemistry 24 (27): 8037–43. 1986. doi:10.1021/bi00348a030. PMID 3004571. 
• "Human urinary kallikrein--amino acid sequence and carbohydrate attachment sites.". Protein Seq. Data Anal. 1 (3): 177–82. 1988. PMID 3163150. 
• "N-terminal amino acid sequence of human urinary prokallikrein.". J. Biochem. 99 (3): 989–92. 1986. doi:10.1093/oxfordjournals.jbchem.a135563. PMID 3635530. 
• "Human kidney kallikrein: cDNA cloning and sequence analysis.". DNA 4 (6): 445–50. 1986. doi:10.1089/dna.1985.4.445. PMID 3853975. 
• "Evaluation of the extent of the binding site in human tissue kallikrein by synthetic substrates with sequences of human kininogen fragments.". Biochem. J. 312 (1): 233–8. 1996. doi:10.1042/bj3120233. PMID 7492318. 
• "Molecular cloning, purification and in situ localization of human colon kallikrein.". Biochem. J. 307 (2): 481–6. 1995. doi:10.1042/bj3070481. PMID 7733886. 
• "Glandular kallikrein gene expression in the human uterus.". Braz. J. Med. Biol. Res. 27 (8): 1855–63. 1995. PMID 7749374. 
• "Molecular cloning and sequence analysis of the monkey and human tissue kallikrein genes.". Biochim. Biophys. Acta 1173 (3): 325–8. 1993. doi:10.1016/0167-4781(93)90131-v. PMID 7916636. 
• "Characterization of kininogenase activity of an acidic proteinase isolated from human kidney.". Can. J. Physiol. Pharmacol. 75 (6): 757–61. 1997. doi:10.1139/cjpp-75-6-757. PMID 9276160. 
• "Serpin-derived peptide substrates for investigating the substrate specificity of human tissue kallikreins hK1 and hK2.". J. Biol. Chem. 272 (47): 29590–5. 1997. doi:10.1074/jbc.272.47.29590. PMID 9368023. 
• "Reactive-site specificity of human kallistatin toward tissue kallikrein probed by site-directed mutagenesis.". Biochim. Biophys. Acta 1479 (1–2): 237–46. 2000. doi:10.1016/S0167-4838(00)00044-3. PMID 10862973. 

External links

• The MEROPS online database for peptidases and their inhibitors: S01.160