Biology:(Histone-H3)-lysine-36 demethylase
From HandWiki
Short description: Class of enzymes
| (Histone-H3)-lysine-36 demethylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.14.11.27 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
(Histone-H3)-lysine-36 demethylase (EC 1.14.11.27, JHDM1A, JmjC domain-containing histone demethylase 1A, H3-K36-specific demethylase, histone-lysine (H3-K36) demethylase, histone demethylase, protein-6-N,6-N-dimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase) is an enzyme with systematic name protein-N6,N6-dimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase.[1] This enzyme catalyses the following chemical reaction
- protein N6,N6-dimethyl-L-lysine + 2 2-oxoglutarate + 2 O2 [math]\displaystyle{ \rightleftharpoons }[/math] protein L-lysine + 2 succinate + 2 formaldehyde + 2 CO2 (overall reaction)
- (1a) protein N6,N6-dimethyl-L-lysine + 2-oxoglutarate + O2 [math]\displaystyle{ \rightleftharpoons }[/math] protein N6-methyl-L-lysine + succinate + formaldehyde + CO2
- (1b) protein N6-methyl-L-lysine + 2-oxoglutarate + O2 [math]\displaystyle{ \rightleftharpoons }[/math] protein L-lysine + succinate + formaldehyde + CO2
(Histone-H3)-lysine-36 demethylase contains iron(II).
References
- ↑ "Histone demethylation by a family of JmjC domain-containing proteins". Nature 439 (7078): 811–6. February 2006. doi:10.1038/nature04433. PMID 16362057. Bibcode: 2006Natur.439..811T.
External links
- (histone-H3)-lysine-36+demethylase at the US National Library of Medicine Medical Subject Headings (MeSH)
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