Biology:2-Deoxy-scyllo-inosamine dehydrogenase (SAM-dependent)
From HandWiki
Short description: Enzyme
| 2-deoxy-scyllo-inosamine dehydrogenase (SAM-dependent) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.1.99.38 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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2-deoxy-scyllo-inosamine dehydrogenase (SAM-dependent) (EC 1.1.99.38, btrN (gene)) is an enzyme with systematic name 2-deoxy-scyllo-inosamine:S-adenosyl-L-methionine 1-oxidoreductase.[1][2] This enzyme catalyses the following chemical reaction
- 2-deoxy-scyllo-inosamine + S-adenosyl-L-methionine [math]\displaystyle{ \rightleftharpoons }[/math] 3-amino-2,3-dideoxy-scyllo-inosose + 5'-deoxyadenosine + L-methionine
This enzyme participates in the biosynthetic pathway of the aminoglycoside antibiotics of the butirosin family.
References
- ↑ "Characterization and mechanistic study of a radical SAM dehydrogenase in the biosynthesis of butirosin". Journal of the American Chemical Society 129 (49): 15147–55. December 2007. doi:10.1021/ja072481t. PMID 18001019.
- ↑ "Mechanistic study on the reaction of a radical SAM dehydrogenase BtrN by electron paramagnetic resonance spectroscopy". Biochemistry 47 (34): 8950–60. August 2008. doi:10.1021/bi800509x. PMID 18672902.
External links
- 2-deoxy-scyllo-inosamine+dehydrogenase+(SAM-dependent) at the US National Library of Medicine Medical Subject Headings (MeSH)
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